1. Metabolic Enzyme/Protease
  2. Mitochondrial Metabolism
  3. Mitochondrial fusion promoter M1

Mitochondrial fusion promoter M1 

Cat. No.: HY-111475 Purity: 99.87%
Handling Instructions

Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator. Mitochondrial fusion promoter M1 preserves the mitochondrial function and promotes cellular respiration. Mitochondrial fusion promoter M1 alleviates cardiac and brain damage in rats with cardiac ischemia/reperfusion injury.

For research use only. We do not sell to patients.

Mitochondrial fusion promoter M1 Chemical Structure

Mitochondrial fusion promoter M1 Chemical Structure

CAS No. : 219315-22-7

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Based on 1 publication(s) in Google Scholar

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Description

Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator. Mitochondrial fusion promoter M1 preserves the mitochondrial function and promotes cellular respiration. Mitochondrial fusion promoter M1 alleviates cardiac and brain damage in rats with cardiac ischemia/reperfusion injury[1][2][3].

In Vitro

Mitochondrial fusion promoter M1 (5-25 μM; 24 h) promotes mitochondrial elongation in both Mitofusin-1 and Mitofusin -2 knock-out fibroblasts[2].
Mitochondrial fusion promoter M1 (20 μM; 12 h) decreases mito ROS to 1.0±0.44 fold, enhances mitochondrial membrane potential from 0.29±0.05 fold to 0.5±0.07 fold and restores mitochondrial architecture in BRIN-BD11 pancreatic beta cells[3].
Mitochondrial fusion promoter M1 (20 μM; 12 h) prevents the impairment of oxygen consumption rate in pancreatic beta cells due to cholesterol exposure[3].
Mitochondrial fusion promoter M1 (20 μM; 12 h) prevents the impairment of non-mitochondrial respiration and extracellular acidification rate (ECAR) in cholesterol enriched pancreatic beta cells[3].
Mitochondrial fusion promoter M1 (20 μM; 12 h) restores Glucose Stimulated Insulin Secretion (GSIS) in cholesterol treated pancreatic beta cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Mitochondrial fusion promoter M1 (2 mg/kg; i.v.) significantly protects rats with cardiac I/R injury against brain damage[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (250-300g) receiving cardiac ischemia/reperfusion (I/R)[1]
Dosage: 2 mg/kg
Administration: I.v. 15 minutes before cardiac I/R injury
Result: Increased brain mitochondrial fusion.
Increased blood-brain barrier (BBB) tight junction protein, and reduced macrophage infiltration in the brain.
Reduced brain mitochondrial dysfunction and apoptosis, but it did not reduce mitochondrial oxidative stress.
Reduced the expression of Alzheimer’s disease (AD)-related proteins.
Molecular Weight

364.05

Formula

C₁₄H₁₀Cl₄N₂O

CAS No.

219315-22-7

SMILES

C/C(C1=CC(Cl)=CC=C1O)=N\NC2=C(Cl)C=C(Cl)C=C2Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (137.34 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7469 mL 13.7344 mL 27.4688 mL
5 mM 0.5494 mL 2.7469 mL 5.4938 mL
10 mM 0.2747 mL 1.3734 mL 2.7469 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.71 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Mitochondrial fusion promoter M1Mitochondrial fusion promoter M 1Mitochondrial fusion promoter M-1Mitochondrial MetabolismcardiacbraindamageischemiareperfusioninjuryInhibitorinhibitorinhibit

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Product Name:
Mitochondrial fusion promoter M1
Cat. No.:
HY-111475
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