1. Metabolic Enzyme/Protease
  2. Mitochondrial Metabolism
  3. HQNO

HQNO 

Cat. No.: HY-130055 Purity: 98.04%
Handling Instructions

HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a Kd of 64 nM for complex III. HQNO is a potent inhibitor of mitochondrial NDH-2 in many species.

For research use only. We do not sell to patients.

HQNO Chemical Structure

HQNO Chemical Structure

CAS No. : 341-88-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 320 In-stock
Estimated Time of Arrival: December 31
100 mg USD 550 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a Kd of 64 nM for complex III[1]. HQNO is a potent inhibitor of mitochondrial NDH-2 in many species[2].

IC50 & Target

NDH-2[2]

In Vitro

HQNO is a potent inhibitor of mitochondrial type II NADH:quinone oxidoreductase (NDH-2) in many species, including Yarrowia lipolytica, S. cerevisiae, Gluconobacter oxydans, T. gondii, P. falciparum, and S. aureus. HQNO targets the Q-site of NDH-2[2].
HQNO concentrations are varied from 0 to 100 μM and 0 to 300 μM for wild-type (WT) and I379E C. thermarum NDH-2 variant, respectively to determine IC50 values. WT NDH-2 has an IC50 value of 10.5±1.3 μM HQNO in the presence of 400 μM Menadione (MD). In the presence of 50 μM MD, the IC50 value for HQNO decreases slightly to 7.3±1.2 μM and near complete inhibition (~15% residual activity) is observed with >50 μM HQNO. At 50 μM MD, HQNO inhibition is observed with an IC50 value of 54.3±1.2 μM[2].

Molecular Weight

259.34

Formula

C₁₆H₂₁NO₂

CAS No.

341-88-8

SMILES

OC(C1=C2C=CC=C1)=CC(CCCCCCC)=N2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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Keywords:

HQNOMitochondrial Metabolismelectrontransportchaincomplex IIImitochondrialNDH-2Inhibitorinhibitorinhibit

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HQNO
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HY-130055
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