341-88-8
341-88-8
Chemical Structure
HQNO
- CAS No.: 341-88-8
- Formula:C16H21NO2
- Molecular Weight:259.34
IUPAC Name: 2-heptyl-4-hydroxyquinoline 1-oxide
InChIKey: NZPACTGCRWDXCJ-UHFFFAOYSA-N
SMILES: OC(C1=C2C=CC=C1)=CC(CCCCCCC)=N2=O
Biological Activity: HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a Kd of 64 nM for complex III[1]. HQNO is a potent inhibitor of mitochondrial NDH-2 in many species[2].
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HQNO | 98.73% | HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a Kd of 64 nM for complex III. HQNO is a potent inhibitor of mitochondrial NDH-2 in many species. | ||||||||||||||||||||
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HQNO (Standard) | ≥98% | HQNO (Standard) is the analytical standard of HQNO. This product is intended for research and analytical applications. HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a Kd of 64 nM for complex III. HQNO is a potent inhibitor of mitochondrial NDH-2 in many species. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.80
HY-W5723862-n-Heptyl-4-quinolinol -
Similarity Score 0.70
HY-1295032-Heptyl-4-quinolone -
Similarity Score 0.70
HY-128200Pseudomonas quinolone signal -
Similarity Score 0.69
HY-4023212-Octyl-4(1H)-quinolone -
Similarity Score 0.68
HY-W555382Pseudane IX -
Similarity Score 0.68
HY-N4164Schinifoline -
Similarity Score 0.67
HY-1243522-Nonyl-3-hydroxy-4-quinolone -
Similarity Score 0.65
HY-169764Pseudane V -
Similarity Score 0.65
HY-N16361-Methyl-2-nonyl-4(1H)-quinolone -
Explore the MedChemAI to find more analogs
References
- [1]. N J Jacobs, et al. Evidence for Involvement of the Electron Transport System at a Late Step of Anaerobic Microbial Heme Synthesis. Biochim Biophys Acta. 1977 Jan 6;459(1):141-4. [Content Brief]
- [2]. Jessica Petri, et al. Structure of the NDH-2 - HQNO Inhibited Complex Provides Molecular Insight Into Quinone-Binding Site Inhibitors. Biochim Biophys Acta Bioenerg. 2018 Jul;1859(7):482-490. [Content Brief]
