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Monactin 

Cat. No.: HY-111525
Handling Instructions

Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity.

For research use only. We do not sell to patients.

Monactin Chemical Structure

Monactin Chemical Structure

CAS No. : 7182-54-9

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Description

Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity[1][2][3].

In Vitro

Monactin displays strong antiproliferative activity against A2780 ovarian cancer cells (IC50 0.13 μM), A2058 melanoma cells (0.02 μM), and H522-T1 non small-cell cancer lung cells (0.01 μM)[3].
Monactin inhibits TCF/β-catenin transcriptional activity[4].
At a concentration of 10 μM, nigericin and monactin inhibited growth of Streptococcus faecalis, and the inhibition was reversed by addition of excess K(+)[5].

In Vivo

Monactin is potent uncoupler of oxidative phosphorylation and inducer of ATP hydrolysis in rat liver mitochondria[1].

Molecular Weight

750.96

Formula

C₄₁H₆₆O₁₂

CAS No.

7182-54-9

SMILES
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

MonactinBacterialtranscriptionalmactrotetralideionophorecationsantiproliferativeInhibitorinhibitorinhibit

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