1. Metabolic Enzyme/Protease
  2. Cathepsin
  3. MK-0674

MK-0674 

Cat. No.: HY-10290
Handling Instructions

MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S.

For research use only. We do not sell to patients.

MK-0674 Chemical Structure

MK-0674 Chemical Structure

CAS No. : 887781-62-6

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Description

MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S[1].

IC50 & Target

IC50: 0.4 nM (Cathepsin K)[1]

In Vitro

MK-0674 (Compound 13) is potent in bone resorption in rabbit osteoclasts, with an IC50 of 10 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

527.50

Formula

C26H27F6N3O2

CAS No.
SMILES

FC(F)(F)[[email protected]](C1=CC=C(C2=CC=C(C=C2)[[email protected]@H](O)C(F)F)C=C1)N[[email protected]@H](CC(C)(F)C)C(NC3(CC3)C#N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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MK-0674
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HY-10290
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