1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. LOE 908 hydrochloride

LOE 908 hydrochloride 

Cat. No.: HY-107756
Handling Instructions

LOE 908 hydrochloride is a non-selective cation channel (NSCC) inhibitor.

For research use only. We do not sell to patients.

LOE 908 hydrochloride Chemical Structure

LOE 908 hydrochloride Chemical Structure

CAS No. : 143482-60-4

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LOE 908 hydrochloride is a non-selective cation channel (NSCC) inhibitor[1].

In Vitro

LOE 908 hydrochloride blocks cation conductance in a concentration-dependent manner with an IC50 of 560 nM, and blocks dihydropyridine-sensitive Ba2+ current through voltage-dependent Ca2+ channels with an IC50 of 28 μM in voltage-clamped A7r5 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

LOE 908 (4 or 2 mg/kg followed by 160 or 80 mg/kg; i.v.) hydrochloride attenuates acute neuromotor dysfunction in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats, lateral fluid percussion brain injury model[2]
Dosage: 4 mg/kg bolus followed by 160 mg/kg over 24 h or 2 mg/kg bolus followed by 80 mg/kg over 24 h
Administration: Intravenous administration
Result: Significantly improved neuromotor function at 48 h postinjury when compared to vehicle treatment.
Molecular Weight







Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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