LOE 908 hydrochloride

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LOE 908 hydrochloride is a non-selective cation channel (NSCC) inhibitor.

For research use only. We do not sell to patients.

LOE 908 hydrochloride Chemical Structure

CAS No. : 143482-60-4

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Biological Activity
Purity & Documentation
References
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Description

LOE 908 hydrochloride is a non-selective cation channel (NSCC) inhibitor^[1].

In Vitro

LOE 908 hydrochloride blocks cation conductance in a concentration-dependent manner with an IC₅₀ of 560 nM, and blocks dihydropyridine-sensitive Ba²⁺ current through voltage-dependent Ca²⁺ channels with an IC₅₀ of 28 μM in voltage-clamped A7r5 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

LOE 908 (4 or 2 mg/kg followed by 160 or 80 mg/kg; i.v.) hydrochloride attenuates acute neuromotor dysfunction in rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male Sprague-Dawley rats, lateral fluid percussion brain injury model^[2]
Dosage:	4 mg/kg bolus followed by 160 mg/kg over 24 h or 2 mg/kg bolus followed by 80 mg/kg over 24 h
Administration:	Intravenous administration
Result:	Significantly improved neuromotor function at 48 h postinjury when compared to vehicle treatment.

Molecular Weight

749.29

Formula

C₄₁H₄₉ClN₂O₉

CAS No.

143482-60-4

SMILES

COC(C(OC)=C(OC)C=C1)=C1CCN(CCC2=C(C(OC)=C(OC)C=C2)OC)C(C(C3=CC=CC=C3)C4=NCCC5=CC(OC)=C(OC)C=C45)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Krautwurst D, et al. The isoquinoline derivative LOE 908 selectively blocks vasopressin-activated nonselective cation currents in A7r5 aortic smooth muscle cells. Naunyn Schmiedebergs Arch Pharmacol. 1994 Mar;349(3):301-7. [Content Brief]

[2]. Cheney JA, et al. The novel compound LOE 908 attenuates acute neuromotor dysfunction but not cognitive impairment or cortical tissue loss following traumatic brain injury in rats. J Neurotrauma. 2000 Jan;17(1):83-91. [Content Brief]