Bertilimumab
Based on 1 Customer Validation
Bertilimumab (CAT 213; iCo-008) is a human monoclonal antibody targeting eotaxin-1 (CCL11). Bertilimumab has the potential for allergic disorders research.
For research use only. We do not sell to patients.
- Purity: 97.01%
- CAS No.: 375348-49-5
- Molecular Weight:144.18 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human IgG4 kappa
Human
CCL11
Bertilimumab (CAT 213) neutralizes the ability of eotaxin-1 to cause an increase in intracellular calcium signaling (with an IC50 value of 2.86 nM), migration of CCR3-expressing L1.2 cells (with an IC50 value of 0.48 nM), and inhibition of the eotaxin1-evoked shape change of human eosinophils in vitro (with an IC50 of 0.71 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female BALB/c mice (17-21 g) injected human eotaxin1[1].
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Dosage:0.01 mg/kg, 0.1 mg/kg, 1 mg/kg, 10 mg/kg
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Administration:i.v; once
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Result:Caused a significant dose-dependent inhibition of eosinophil recruitment in IL-5-treated, ovalbumin-sensitized mice.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG4 kappa
ELISA, FACS, Functional assay
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Immobilized Eotaxin/CCL11 Protein, Human, HY-P7159 can bind Bertilimumab. The EC50 for this effect is 3.458 ng/mL.
Chemical Information
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CAS No. 375348-49-5
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Appearance Liquid
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Molecular Weight 144.18 kDa
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Color Colorless to light yellow
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SMILES
[Bertilimumab]
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Synonyms
CAT 213; iCo-008
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (259 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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