Gramicidin A TFA
Based on 1 publication(s) in Google Scholar
Gramicidin A (TFA) is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A (TFA) is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A (TFA) induces degradation of hypoxia inducible factor 1 α (HIF-1α).
For research use only. We do not sell to patients.
- Formula: C99H140N20O17·xC2HF3O2
- Molecular Weight:1882.29 (free base)
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Gramicidin A TFA
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Biological Activity
Chemical Information
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Molecular Weight 1882.29 (free base)
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Formula C99H140N20O17·xC2HF3O2
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Sequence
{For}-Val-Gly-Ala-{d-Leu}-Ala-{d-Val}-Val-{d-Val}-Trp-{d-Leu}-Trp-{d-Leu}-Trp-{d-Leu}-Trp-{MEA}
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Sequence Shortening
{For}-VGA-{d-Leu}-A-{d-Val}-V-{d-Val}-W-{d-Leu}-W-{d-Leu}-W-{d-Leu}-W-{MEA}
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Rep Med
Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice. [Abstract]2023 Mar 21;4(3):100957. PMID: 36889319
Purity & Documentation
References
[1]. Takada Y, et al. Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library. Nat Commun. 2020 Oct 1;11(1):4935. [Content Brief]
[2]. David JM, et al. Gramicidin A induces metabolic dysfunction and energy depletion leading to cell death in renal cell carcinoma cells. Mol Cancer Ther. 2013 Nov;12(11):2296-307. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Gramicidin A TFA Related Classifications
HY-P2324A Related Classifications
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