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Cat. No.: HY-100231

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Cathepsin inhibitor 1

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

Cathepsin inhibitor 1 (Compound 25) is a potent and selective inhibitor of Cathepsin, with pIC₅₀s of 7.9, 6.7, 6.0, 5.5 and 5.2 for CatL, CatL2, CatS, CatK, and CatB, respectively. Cathepsin inhibitor 1 is promising for research of osteoarthritis.

For research use only. We do not sell to patients.

Purity: 99.28%
CAS No.: 225120-65-0
Formula: C₂₀H₂₄ClN₅O₂
Molecular Weight:401.89

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Cathepsin inhibitor 1 Chemical Structure

CAS No.: 225120-65-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Cathepsin Isoforms :

In Vitro

The CatL pIC₅₀ value of Cathepsin inhibitor 1^[1]

Compd	CatL pIC₅₀	CatL2 pIC₅₀	CatS pIC₅₀	CatK pIC₅₀	CatB pIC₅₀
Cathepsin inhibitor 1	7.9	6.7	6.0	5.5	5.2

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 225120-65-0
Appearance Solid
Molecular Weight 401.89
Formula C₂₀H₂₄ClN₅O₂
Color White to off-white
SMILES

O=C(C1=CC(C(C)(C)C)=NN1C)N[C@@H](CC2=CC=CC(Cl)=C2)C(NCC#N)=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Research Square Print

2025 May 28.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (248.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4882 mL

12.4412 mL

24.8824 mL

5 mM

0.4976 mL

2.4882 mL

4.9765 mL

10 mM

0.2488 mL

1.2441 mL

2.4882 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Asaad N, et, al. Dipeptidyl nitrile inhibitors of Cathepsin L. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4280-3. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.4882 mL	12.4412 mL	24.8824 mL	62.2061 mL
	5 mM	0.4976 mL	2.4882 mL	4.9765 mL	12.4412 mL
	10 mM	0.2488 mL	1.2441 mL	2.4882 mL	6.2206 mL
	15 mM	0.1659 mL	0.8294 mL	1.6588 mL	4.1471 mL
	20 mM	0.1244 mL	0.6221 mL	1.2441 mL	3.1103 mL
	25 mM	0.0995 mL	0.4976 mL	0.9953 mL	2.4882 mL
	30 mM	0.0829 mL	0.4147 mL	0.8294 mL	2.0735 mL
	40 mM	0.0622 mL	0.3110 mL	0.6221 mL	1.5552 mL
	50 mM	0.0498 mL	0.2488 mL	0.4976 mL	1.2441 mL
	60 mM	0.0415 mL	0.2074 mL	0.4147 mL	1.0368 mL
	80 mM	0.0311 mL	0.1555 mL	0.3110 mL	0.7776 mL
	100 mM	0.0249 mL	0.1244 mL	0.2488 mL	0.6221 mL

Keywords

Cathepsin inhibitor 1

1 Cited Publications

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Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References

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Cathepsin inhibitor 1

Bioactive Compound Library Max

Bioactive Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

Covalent Screening Library

Angiogenesis-Related Compound Library

Heterocyclic Compound Library

Protease Inhibitor Library

Highly Selective Inhibitors Library

MCE Bioactive Compound Library

Covalent Screening Library Plus

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) Cathepsin inhibitor 1

All Cathepsin Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Cathepsin inhibitor 1

Bioactive Compound Library Max

Bioactive Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

Covalent Screening Library

Angiogenesis-Related Compound Library

Heterocyclic Compound Library

Protease Inhibitor Library

Highly Selective Inhibitors Library

MCE Bioactive Compound Library

Covalent Screening Library Plus

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) Cathepsin inhibitor 1

All Cathepsin Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Cathepsin inhibitor 1 Related Classifications

HY-100231 Related Classifications