2. Anti-infection
  3. Bacterial Fungal
  4. Thanatin TFA

Thanatin TFA is an inducible cationic antimicrobial peptide. Thanatin TFA s a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin TFA displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin TFA has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption.

For research use only. We do not sell to patients.

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Thanatin TFA Chemical Structure

Thanatin TFA Chemical Structure

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Based on 1 publication(s) in Google Scholar

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Thanatin TFA Related Antibodies

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Description

Thanatin TFA is an inducible cationic antimicrobial peptide. Thanatin TFA s a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin TFA displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin TFA has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption[1][2].

In Vitro

Thanatin TFA is strongly cationic (pI of 10.48) and contains a distinct short eight-residue basic loop created through a disulfide bond formation between residues Cys11 and Cys18 at the C-terminus. [1].
Thanatin TFA exhibits potent inhibitory effect on the growth of all New Delhi metallo-β-lactamase-1 (NDM-1)-producing E. coli and K. pneumoniae strains at 0.4-3.2 μM of the minimum inhibitory concentration (MIC) values[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thanatin TFA Related Antibodies
In Vivo

Thanatin (1, 3, 6 mg/kg; ip; at 1 and 6 h) TFA protects mice infected with NDM-1-producing E. coli[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c mice aged 8-10 weeks and weighing 18-22 g with CFU E. coli XJ141026
Dosage: 1, 3, 6 mg/kg
Administration: Intraperitoneally injected; at 1 and 6 h
Result: 1, 3, and 6 mg/kg markedly increased the survival rate from 0 to 30%, 70%, and 100%, respectively.
Showed that the bacterial titers decreased with increasing drug dose.
Rescued the pathological damages (large amounts of inflammatory cell infiltration, alveolar fusion, congestion in the spleen red pulp area, hepatic sinusoidal dilation and congestion) in a dose-dependent manner.
Molecular Weight

2433.92 (free base)

Formula

C103H177N35O27S3.xC2HF3O2
Appearance

Solid

Sequence

Gly-Ser-Lys-Lys-Pro-Val-Pro-Ile-Ile-Tyr-Cys-Asn-Arg-Arg-Thr-Gly-Lys-Cys-Gln-Arg-Met (Disulfide bridge:Cys11-Cys18)
Sequence Shortening

GSKKPVPIIYCNRRTGKCQRM (Disulfide bridge:Cys11-Cys18)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

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Purity & Documentation
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Thanatin TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ThanatinBacterialFungalCationicantimicrobialβ-hairpin AMPGram-negativeGram-positiveouter membraneInhibitorinhibitorinhibit

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