Cat. No.: HY-139192A

Brophenexin free base

(Synonyms: NMDAR/TRPM4-IN-2 free base)

3 Cited Publications

Customer Review

Based on 3 publication(s) in Google Scholar

Brophenexin free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. Brophenexin free base shows neuroprotective activity. Brophenexin free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC₅₀ of 2.1 μM. Brophenexin free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss.

For research use only. We do not sell to patients.

Purity: 99.24%
CAS No.: 1353979-43-7
Formula: C₁₁H₁₇BrN₂
Molecular Weight:257.18

Storage:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Brophenexin free base Chemical Structure

CAS No.: 1353979-43-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (3)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

NMDA Receptor

All iGluR Isoforms :

All TRP Channel Isoforms :

All ERK Isoforms :

In Vitro

Brophenexin free base (compound 8) (0-10 μM) reduces the interactions of GluN2A and GluN2B with TRPM4 in a dose-dependent manner^[1].
Brophenexin free base eliminates the CREB shutoff pathway and restores ERK1/2 activation and IEG induction while sparing the synaptic activity-driven, transcription-promoting activities of NMDARs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1353979-43-7
Appearance Liquid (Density: 1.293 g/cm³)
Molecular Weight 257.18
Formula C₁₁H₁₇BrN₂
Color Colorless to light yellow
SMILES

NCCN(CC1=CC=CC(Br)=C1)CC
Synonyms

NMDAR/TRPM4-IN-2 free base
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (3)

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Journal Impact Factor

Neurotox Res

2026 Mar 6;44(2):11.
Pharmacol Res Perspect

NMDA Receptor-Mediated Ca2+ Flux Attenuated by the NMDA Receptor/TRPM4 Interface Inhibitor Brophenexin. [Abstract]

2024 Dec;12(6):e70038. PMID: 39574295
University of Minnesota

2025.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (388.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.8883 mL

19.4416 mL

38.8833 mL

5 mM

0.7777 mL

3.8883 mL

7.7767 mL

10 mM

0.3888 mL

1.9442 mL

3.8883 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (614 KB)
- English - EN (614 KB)
- Français - FR (614 KB)
- Deutsch - DE (614 KB)
- Norwegian - NO (614 KB)
- Español - ES (614 KB)
- Swedish - SV (614 KB)
- Italian - IT (614 KB)
- Korean - KR (614 KB)
- Portuguese - PT (614 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yan J, et al. Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants. Science. 2020 Oct 9;370(6513):eaay3302. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.8883 mL	19.4416 mL	38.8833 mL	97.2082 mL
	5 mM	0.7777 mL	3.8883 mL	7.7767 mL	19.4416 mL
	10 mM	0.3888 mL	1.9442 mL	3.8883 mL	9.7208 mL
	15 mM	0.2592 mL	1.2961 mL	2.5922 mL	6.4805 mL
	20 mM	0.1944 mL	0.9721 mL	1.9442 mL	4.8604 mL
	25 mM	0.1555 mL	0.7777 mL	1.5553 mL	3.8883 mL
	30 mM	0.1296 mL	0.6481 mL	1.2961 mL	3.2403 mL
	40 mM	0.0972 mL	0.4860 mL	0.9721 mL	2.4302 mL
	50 mM	0.0778 mL	0.3888 mL	0.7777 mL	1.9442 mL
	60 mM	0.0648 mL	0.3240 mL	0.6481 mL	1.6201 mL
	80 mM	0.0486 mL	0.2430 mL	0.4860 mL	1.2151 mL
	100 mM	0.0389 mL	0.1944 mL	0.3888 mL	0.9721 mL

Keywords

Brophenexin free base

3 Cited Publications

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Brophenexin free base

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Publications Citing Use of MedChemExpress (MCE) Brophenexin free base

All iGluR Isoforms

All TRP Channel Isoforms

All ERK Isoforms

Biological Activity

Chemical Information

Publications (3)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Brophenexin free base Related Classifications

HY-139192A Related Classifications