1353979-43-7
Chemical Structure
Brophenexin free base
Synonym(s): NMDAR/TRPM4-IN-2 free base
- CAS No.: 1353979-43-7
- Formula:C11H17BrN2
- Molecular Weight:257.18
IUPAC Name: N1-(3-bromobenzyl)-N1-ethylethane-1,2-diamine
InChIKey: XSMDMHAMGOGFLG-UHFFFAOYSA-N
SMILES: NCCN(CC1=CC=CC(Br)=C1)CC
Biological Activity: Brophenexin free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. Brophenexin free base shows neuroprotective activity. Brophenexin free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. Brophenexin free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss[1].
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Brophenexin free base | 99.24% | Brophenexin free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. Brophenexin free base shows neuroprotective activity. Brophenexin free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. Brophenexin free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss. | ||||||||||||||||||||
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Keywords
