1. GPCR/G Protein
    Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. GPR119
    TRP Channel
  3. AS1269574

AS1269574 

Cat. No.: HY-107535
Handling Instructions

AS1269574 is a potent, orally available GPR119 agonist, with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates TRPA1 cation channels to stimulate glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induces glucose-dependent insulin secretion from pancreatic β-cells only under high-glucose conditions. AS1269574 has the potential for the research of type 2 diabetes.

For research use only. We do not sell to patients.

AS1269574 Chemical Structure

AS1269574 Chemical Structure

CAS No. : 330981-72-1

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Description

AS1269574 is a potent, orally available GPR119 agonist, with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates TRPA1 cation channels to stimulate glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induces glucose-dependent insulin secretion from pancreatic β-cells only under high-glucose conditions. AS1269574 has the potential for the research of type 2 diabetes[1][2].

IC50 & Target[1][2]

GPR119

 

TRPA1

 

In Vivo

AS1269574 sgnificantly reduced the blood glucose AUC after 2 h (AUC0-2h) of administration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old ICR mice[1]
Dosage: 100 mg/kg
Administration: P.o.
Result: Sgnificantly reduced the blood glucose AUC after 2 h (AUC0-2h) of administration. Similarly, plasma insulin AUC0-2h was significantly higher in the mice.
Molecular Weight

308.17

Formula

C₁₃H₁₄BrN₃O

CAS No.

330981-72-1

SMILES

OCCNC1=NC(C2=CC=C(Br)C=C2)=NC(C)=C1

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AS1269574AS 1269574AS-1269574GPR119TRP ChannelG protein coupled receptor 119Transient receptor potential channelsglucoseinsulinsecretioncationchannelstype2diabetesInhibitorinhibitorinhibit

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AS1269574
Cat. No.:
HY-107535
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