AS1269574 (Standard)
AS1269574 (Standard) is the analytical standard of AS1269574 (HY-107535). This product is intended for research and analytical applications. AS1269574 is a potent, orally available GPR119 agonist, with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates TRPA1 cation channels to stimulate glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induces glucose-dependent insulin secretion from pancreatic β-cells only under high-glucose conditions. AS1269574 has the potential for the research of type 2 diabetes.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 330981-72-1
- 分子式: C13H14BrN3O
- 分子量:308.17
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-107535
AS1269574GPR119 Agonist -
HY-15291
MBX-2982GPR119 Agonist -
HY-15565
APD668GPR119 Agonist -
HY-16673
PSN632408GPR119 Agonist -
HY-12066
GSK1292263 -
HY-15564
AR 231453GPR119 Agonist -
HY-108258
PSN 375963GPR119 Agonist -
HY-15566
APD597GPR119 Agonist -
HY-W011121
2-OleoylglycerolGPR119 Agonist -
HY-15589
GW9508GPR40 Agonist -
HY-15565R
APD668 (Standard)GPR119 Agonist -
HY-12764
6-OAUGPR84 Agonist
生物活性
製品説明
化学情報
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CAS 番号 330981-72-1
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分子量 308.17
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分子式 C13H14BrN3O
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SMILES
OCCNC1=NC(C2=CC=C(Br)C=C2)=NC(C)=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Yoshida S, et al. Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated insulin secretion. Biochem Biophys Res Commun. 2010;400(3):437-441. [Content Brief]
[2]. Chepurny OG, et al. GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion. Mol Endocrinol. 2016;30(6):614-629. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AS1269574 (Standard) 関連分類
HY-107535R 関連分類
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