Homobutein 

Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC₅₀s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation^[1][2][3][4].

Homobutein (compound 15) (20, 24, 28, 32, 40 μM; 2 h) inhibits the viability of K562 cells^[1].
Homobutein (2 h) inhibits TNFα-induced NF-κB activity in K562 cells^[1].
Homobutein (1 μg/mL; 72 h) inhibits the growth of Toxoplasma gondii by 19.48%^[2].
Homobutein (24 h) againsts W2 and D6 strains of P.falciparum with IC₅₀s of 15.0 and 16.1 µM, respectively^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

286.28

C₁₆H₁₄O₅

34000-39-0

O=C(C1=CC=C(O)C=C1O)/C=C/C2=CC=C(O)C(OC)=C2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Orlikova B, et al. Natural chalcones as dual inhibitors of HDACs and NF-κB. Oncol Rep. 2012 Sep;28(3):797-805.  [Content Brief]

  [2]. Adeyemi OS, et al. In Vitro Screening to Identify Anti-Toxoplasma Compounds and In Silico Modeling for Bioactivities and Toxicity. Yale J Biol Med. 2019 Sep 20;92(3):369-383.  [Content Brief]

  [3]. Yenesew A, et al. Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica. Phytochemistry. 2004 Nov;65(22):3029-32.  [Content Brief]

  [4]. Serobatse K, et al. Antioxidant and antimalarial properties of butein and homobutein based on their ability to chelate iron (II and III) cations: a DFT study in vacuo and in solution. European Food Research and Technology, 2016, 242(1): 71-90.