Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica

  • Phytochemistry. 2004 Nov;65(22):3029-32. doi: 10.1016/j.phytochem.2004.08.050.
Abiy Yenesew  1 ,  Martha Induli ,  Solomon Derese ,  Jacob O Midiwo ,  Matthias Heydenreich ,  Martin G Peter ,  Hoseah Akala ,  Julia Wangui ,  Pamela Liyala ,  Norman C Waters
Affiliations
  • 1. Department of Chemistry, University of Nairobi, P.O. Box 30197, Chiromo Road, Nairobi, Kenya. [email protected]
PMID: 15504437 DOI: 10.1016/j.phytochem.2004.08.050
Abstract

The ethyl acetate extract of the stem bark of Erythrina abyssinica showed anti-plasmodial activity against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC(50) values of 7.9+/-1.1 and 5.3+/-0.7 microg/ml, respectively. From this extract, a new chalcone, 2',3,4,4'-tetrahydroxy-5-prenylchalcone (trivial name 5-prenylbutein) and a new flavanone, 4',7-dihydroxy-3'-methoxy-5'-prenylflavanone (trivial name, 5-deoxyabyssinin II) along with known Flavonoids have been isolated as the anti-plasmodial principles. The structures were determined on the basis of spectroscopic evidence.

Products