1,4,7-Triazonane
Based on 1 Customer Validation
1,4,7-Triazonane (1,4,7-Triazacyclononane), an intermediate in the synthesis of 1,4,7-trifunctionalized derivatives, is a possible reagent for compleximetric titrations with high cation-binding selectivity.
For research use only. We do not sell to patients.
- Purity: 99.62%
- CAS No.: 4730-54-5
- Formula: C6H15N3
- Molecular Weight:129.20
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L3.6pl | IC50 |
980 μM
Compound: 1,4,7-TCN
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Cytotoxicity against human L3.6pl cells assessed as reduction in cell growth measured after 72 hrs by CellTiter96 one aqueous solution assay
Cytotoxicity against human L3.6pl cells assessed as reduction in cell growth measured after 72 hrs by CellTiter96 one aqueous solution assay
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[PMID: 35178189] |
1,4,7-Triazonane is an intermediate in the synthesis of 1,4,7-trifunctionalized derivatives that have applications in metal complexation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 4730-54-5
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Appearance Solid
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Molecular Weight 129.20
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Formula C6H15N3
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Color White to yellow
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SMILES
C1CNCCNCCN1
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Synonyms
1,4,7-Triazacyclononane
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (773.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (19.35 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (19.35 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (476 KB)
- English - EN (476 KB)
- Français - FR (476 KB)
- Deutsch - DE (476 KB)
- Norwegian - NO (476 KB)
- Español - ES (476 KB)
- Swedish - SV (476 KB)
- Italian - IT (476 KB)
- Korean - KR (476 KB)
- Portuguese - PT (476 KB)
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Handling Instructions (2659 KB)
References
[1]. Nonat A, et, al. Structural and photophysical studies of highly stable lanthanide complexes of tripodal 8-hydroxyquinolinate ligands based on 1,4,7-triazacyclononane. Inorg Chem. 2009 May 4;48(9):4207-18. [Content Brief]
[2]. Guo JF, et, al. trans-[Os(III)(salen)(CN)(2)](-): a new paramagnetic building block for the construction of molecule-based magnetic materials. Inorg Chem. 2010 Feb 15;49(4):1607-14. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.7399 mL | 38.6997 mL | 77.3994 mL | 193.4985 mL |
| 5 mM | 1.5480 mL | 7.7399 mL | 15.4799 mL | 38.6997 mL | |
| 10 mM | 0.7740 mL | 3.8700 mL | 7.7399 mL | 19.3498 mL | |
| 15 mM | 0.5160 mL | 2.5800 mL | 5.1600 mL | 12.8999 mL | |
| 20 mM | 0.3870 mL | 1.9350 mL | 3.8700 mL | 9.6749 mL | |
| 25 mM | 0.3096 mL | 1.5480 mL | 3.0960 mL | 7.7399 mL | |
| 30 mM | 0.2580 mL | 1.2900 mL | 2.5800 mL | 6.4499 mL | |
| 40 mM | 0.1935 mL | 0.9675 mL | 1.9350 mL | 4.8375 mL | |
| 50 mM | 0.1548 mL | 0.7740 mL | 1.5480 mL | 3.8700 mL | |
| 60 mM | 0.1290 mL | 0.6450 mL | 1.2900 mL | 3.2250 mL | |
| 80 mM | 0.0967 mL | 0.4837 mL | 0.9675 mL | 2.4187 mL | |
| 100 mM | 0.0774 mL | 0.3870 mL | 0.7740 mL | 1.9350 mL |
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