2. Anti-infection Apoptosis
  3. Bacterial Fungal Apoptosis Antibiotic
  4. Chromomycin A3

Chromomycin A3 is an aureolic acid-type antitumor antibiotic. Chromomycin A3 forms dimeric complexes with divalent cations, such as Mg2+, which strongly binds to the GC rich sequence of DNA to inhibit DNA replication and transcription. Chromomycin A3 has a variety of utilities as a staining agent for human sperm chromatin, autophagy inducing agent, and apoptosis inhibitor.

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Chromomycin A3 Chemical Structure

Chromomycin A3 Chemical Structure

CAS No. : 7059-24-7

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5 mg USD 230 In-stock
10 mg USD 400 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Chromomycin A3 is an aureolic acid-type antitumor antibiotic. Chromomycin A3 forms dimeric complexes with divalent cations, such as Mg2+, which strongly binds to the GC rich sequence of DNA to inhibit DNA replication and transcription. Chromomycin A3 has a variety of utilities as a staining agent for human sperm chromatin, autophagy inducing agent, and apoptosis inhibitor[1].

Molecular Weight

1183.25

Formula

C57H82O26
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=C(C[C@H]([C@@H]1O[C@](C[C@@H](O[C@](C[C@@H](O[C@@]3([H])C[C@](O)([C@H]([C@@H](O3)C)OC(C)=O)C)[C@@H]4O)([H])O[C@@H]4C)[C@@H]5O)([H])O[C@@H]5C)[C@@H](C([C@H]([C@@H](C)O)O)=O)OC)C=C(C=C6O[C@H]7C[C@H]([C@H]([C@H](O7)C)OC(C)=O)O[C@]8([H])C[C@H]([C@H]([C@H](O8)C)OC)O)C(C(O)=C6C)=C2O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (84.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8451 mL 4.2256 mL 8.4513 mL
5 mM 0.1690 mL 0.8451 mL 1.6903 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.66%

COA (253 KB) HNMR (331 KB) LCMS (273 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8451 mL 4.2256 mL 8.4513 mL 21.1282 mL
5 mM 0.1690 mL 0.8451 mL 1.6903 mL 4.2256 mL
10 mM 0.0845 mL 0.4226 mL 0.8451 mL 2.1128 mL
15 mM 0.0563 mL 0.2817 mL 0.5634 mL 1.4085 mL
20 mM 0.0423 mL 0.2113 mL 0.4226 mL 1.0564 mL
25 mM 0.0338 mL 0.1690 mL 0.3381 mL 0.8451 mL
30 mM 0.0282 mL 0.1409 mL 0.2817 mL 0.7043 mL
40 mM 0.0211 mL 0.1056 mL 0.2113 mL 0.5282 mL
50 mM 0.0169 mL 0.0845 mL 0.1690 mL 0.4226 mL
60 mM 0.0141 mL 0.0704 mL 0.1409 mL 0.3521 mL
80 mM 0.0106 mL 0.0528 mL 0.1056 mL 0.2641 mL
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Chromomycin A3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chromomycin A37059-24-7Chromomycin A 3Chromomycin A-3BacterialFungalApoptosisAntibioticInhibitorinhibitorinhibit

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