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  3. Muramyl dipeptide

Muramyl dipeptide (Synonyms: MDP)

Cat. No.: HY-127090
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Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide is an inducer of bone formation through induction of Runx2. Muramyl dipeptide directly enhances osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide indirectly attenuates osteoclast differentiation through a decreased RANKL/OPG ratio.

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Muramyl dipeptide Chemical Structure

Muramyl dipeptide Chemical Structure

CAS No. : 53678-77-6

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Description

Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide is an inducer of bone formation through induction of Runx2. Muramyl dipeptide directly enhances osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide indirectly attenuates osteoclast differentiation through a decreased RANKL/OPG ratio[1].

In Vitro

Muramyl dipeptide (0.1-10 µg/mL; 24 hours) increases protein expression of Runx2 in a dose-dependent manner[1].
Muramyl dipeptide (0.1-10 µg/mL; 6 hours) increases mRNA levels of Runx2 in a dose-dependent manner[1].

Western Blot Analysis[1]

Cell Line: MC3T3-E1 cells
Concentration: 0.1, 1, 10 µg/mL
Incubation Time: 24 hours
Result: Increased protein expression of Runx2 in a dose-dependent manner.

RT-PCR[1]

Cell Line: MC3T3-E1 cells
Concentration: 0.1, 1, 10 µg/mL
Incubation Time: 6 hours
Result: Increases mRNA levels of Runx2 in a dose-dependent manner.
In Vivo

Muramyl dipeptide (1.25 mg/kg; i.p.; twice) alleviates bone loss induced by osteoporosis[1].

Animal Model: RANKL-induced osteoporosis model (Five-week-old C57BL/6 mice)[1]
Dosage: 1.25 mg/kg
Administration: i.p.; twice (RANKL-induced osteoporosis for 3 weeks and euthanized at 4 weeks)
Result: Significantly enhanced the trabecular bone volume (BV/TV) and trabecular number (Tb.N).
Molecular Weight

492.48

Formula

C₁₉H₃₂N₄O₁₁

CAS No.

53678-77-6

SMILES
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Keywords:

Muramyl dipeptideMDPp38 MAPKERKJNKExtracellular signal regulated kinasesc-Jun N-terminal kinasepeptidoglycansboneformationNod2osteoblastosteoclastdifferentiationRANKL/OPGratioinductionInhibitorinhibitorinhibit

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Muramyl dipeptide
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