PF-00956980
PF-00956980 is a reversible pan-JAK inhibitor with IC50 values of 2.2, 23.1 and 59.9 μM for JAK1, JAK2 and JAK3, respectively. PF-00956980 can be used in the research of lung and skin inflammatory diseases.
For research use only. We do not sell to patients.
- CAS No.: 1262832-74-5
- Formula: C18H26N6O
- Molecular Weight:342.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
JAK1 2.2 μM (IC50) |
JAK2 23.1 μM (IC50) |
JAK3 59.9 μM (IC50) |
In Vivo
| Spesies | Dose (mg/kg) | Cl (mL/min/Kg) | Clunbound (mL/min/Kg) | Vss (L/Kg) | Terminal T1/2 (h) | Oral Bioavailability |
| Rat i.v. | 0.5 | 48 | >48,000 | 0.8 | 2.1 | - |
| Rat p.o. | 1 | - | - | - | - | <5% |
| Dog i.v. | 0.1 | 18 | >18,000 | 1.0 | 2.0 | - |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1262832-74-5
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Molecular Weight 342.44
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Formula C18H26N6O
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SMILES
O=C(N1C[C@H](N(C)C2=C3C(NC=C3)=NC=N2)[C@H](C)CC1)N4CCCC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PF-00956980 Related Classifications
HY-108342 Related Classifications
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