PF-00956980
PF-00956980 is a reversible pan-JAK inhibitor with IC50 values of 2.2, 23.1 and 59.9 μM for JAK1, JAK2 and JAK3, respectively. PF-00956980 can be used in the research of lung and skin inflammatory diseases.
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- No. CAS: 1262832-74-5
- Fòrmula: C18H26N6O
- Peso molecular:342.44
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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JAK1 2.2 μM (IC50) |
JAK2 23.1 μM (IC50) |
JAK3 59.9 μM (IC50) |
| Spesies | Dose (mg/kg) | Cl (mL/min/Kg) | Clunbound (mL/min/Kg) | Vss (L/Kg) | Terminal T1/2 (h) | Oral Bioavailability |
| Rat i.v. | 0.5 | 48 | >48,000 | 0.8 | 2.1 | - |
| Rat p.o. | 1 | - | - | - | - | <5% |
| Dog i.v. | 0.1 | 18 | >18,000 | 1.0 | 2.0 | - |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1262832-74-5
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Peso molecular 342.44
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Fòrmula C18H26N6O
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SMILES
O=C(N1C[C@H](N(C)C2=C3C(NC=C3)=NC=N2)[C@H](C)CC1)N4CCCC4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PF-00956980 Related Classifications
HY-108342 Related Classifications
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