1. Immunology/Inflammation
  2. COX
  3. Sudoxicam

Sudoxicam 

Cat. No.: HY-106628
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Sudoxicam is a reversible and orally active COX antagonist and a non-steroidal anti-inflammatory drug (NSAID) from the enol-carboxamide class. Sudoxicam has potent anti-inflammatory, anti-edema and antipyretic activity.

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Sudoxicam Chemical Structure

Sudoxicam Chemical Structure

CAS No. : 34042-85-8

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Description

Sudoxicam is a reversible and orally active COX antagonist and a non-steroidal anti-inflammatory drug (NSAID) from the enol-carboxamide class. Sudoxicam has potent anti-inflammatory, anti-edema and antipyretic activity[1][2][3].

IC50 & Target

COX[3]

In Vitro

Sudoxicam demonstrates NADPH-dependent covalent binding to human liver microsomes. With addition of glutathione (GSH) in microsomal incubations, about half of the covalent incorporation of Sudoxicam is blocked by addition of GSH[1].
Metabolite identification studies on [14C]-Sudoxicam in NADPH-supplemented human liver microsomes indicated that the primary route of metabolism involved a P450-mediated thiazole ring scission to the corresponding acylthiourea metabolite (S3), a well-established pro-toxin[1].
In vitro, Sudoxicam underwent the oxidative thiazole-open biotransformation, resulting in the formation of an acylthiourea and the subsequent hydroxylated metabolite[3].

In Vivo

Sudoxicam (1-10 mg/kg; oral administration; daily; for 7 days; rats) treatment effective reduces plasma inflammation units, reduces the swelling of inflamed hind-paws and restores toward normal the daily gain in body weight[2].
In the intact rat, Sudoxicam significantly inhibited edema formation at doses as low as 0.1 mg/kg, p.o[2].
Sudoxicam inhibits the erythema caused by ultraviolet irradiation in the guinea pig. Sudoxicam (3.3 mg/kg, i.p.) is capable of counteracting the pyrexia induced by the intraperitoneal injection of typhoid/paratyphoid vaccine in rats, maintaining body temperature about that of uninjected control rats[2].
The plasma half-life of Sudoxicam ranged between 8 hours (monkey), 13 hours (rat), and 60 hours (dog)[2].

Animal Model: Rats injected with ,i>M. butyrieum[2]
Dosage: 1 mg/kg, 3.3 mg/kg, 10 mg/kg
Administration: Oral administration; daily; for 7 days
Result: Were both effective in reducing plasma inflammation units, in reducing the swelling of inflamed hind-paws.
Molecular Weight

337.37

Formula

C₁₃H₁₁N₃O₄S₂

CAS No.

34042-85-8

SMILES

OC(C1=CC=CC=C12)=C(C(NC3=NC=CS3)=O)N(C)S2(=O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SudoxicamCOXCyclooxygenaseNSAIDenol-carboxamideanti-inflammatoryGSHNADPHmicrosomescovalentanti-edemaantipyreticInhibitorinhibitorinhibit

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Sudoxicam
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