CXCR7 antagonist-1 hydrochloride
Based on 2 publication(s) in Google Scholar
CXCR7 antagonist-1 hydrochloride is a CXCR7 antagonist that inhibits the binding of the SDF-1 chemokine (also known as the CXCL12 chemokine) or I-TAC (also known as CXCL11) to the chemokine receptor CXCR7. CXCR7 antagonist-1 hydrochloride is useful in preventing tumor cell proliferation, tumor formation, inflammatory diseases, and many other diseases.
For research use only. We do not sell to patients.
- Purity: 99.41%
- CAS No.: 2990472-61-0
- Formula: C21H20ClFN6O
- Molecular Weight:426.87
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) CXCR7 antagonist-1 hydrochloride
MoreAll Adrenergic Receptor Isoforms
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Biological Activity
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CXCR7 |
CXCR7 antagonist-1 hydrochloride (10 μM, 48 h) restores CXCL11 or respiratory syncytial virus (RSV) infection-induced β2-adrenergic receptor (β2AR) downregulation and the muscle relaxation in infant airway smooth muscle cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:infant airway smooth muscle cells
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Concentration:10 μM
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Incubation Time:48 h
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Result:Inhibited the expression of β2AR.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:RSV-infected BALB/c mouse models[2]
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Dosage:10 μM
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Administration:intranasal instillation, once a day on days 7 and 8 after RSV infection.
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Result:Improved the impaired airway relaxation response to β2AR agonists, restored the airway relaxation function.
Chemical Information
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CAS No. 2990472-61-0
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Appearance Solid
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Molecular Weight 426.87
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Formula C21H20ClFN6O
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Color Light yellow to green yellow
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SMILES
O=C(C1=NN(C2=CC=C(C=C2)F)C=C1)N[C@@H]3CN(CC3)C4=NC=CN5C4=CC=C5.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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bioRxiv
Infant RSV infection desensitizes β2-adrenergic receptor via CXCL11-CXCR7 signaling in airway smooth muscle. [Abstract]2025 Jan 15:2025.01.13.632772. PMID: 39868223
Solvent & Solubility
DMSO : 350 mg/mL (819.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 8.75 mg/mL (20.50 mM); Clear solution
This protocol yields a clear solution of ≥ 8.75 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (87.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 8.75 mg/mL (20.50 mM); Clear solution
This protocol yields a clear solution of ≥ 8.75 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (87.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3426 mL | 11.7132 mL | 23.4263 mL | 58.5658 mL |
| 5 mM | 0.4685 mL | 2.3426 mL | 4.6853 mL | 11.7132 mL | |
| 10 mM | 0.2343 mL | 1.1713 mL | 2.3426 mL | 5.8566 mL | |
| 15 mM | 0.1562 mL | 0.7809 mL | 1.5618 mL | 3.9044 mL | |
| 20 mM | 0.1171 mL | 0.5857 mL | 1.1713 mL | 2.9283 mL | |
| 25 mM | 0.0937 mL | 0.4685 mL | 0.9371 mL | 2.3426 mL | |
| 30 mM | 0.0781 mL | 0.3904 mL | 0.7809 mL | 1.9522 mL | |
| 40 mM | 0.0586 mL | 0.2928 mL | 0.5857 mL | 1.4641 mL | |
| 50 mM | 0.0469 mL | 0.2343 mL | 0.4685 mL | 1.1713 mL | |
| 60 mM | 0.0390 mL | 0.1952 mL | 0.3904 mL | 0.9761 mL | |
| 80 mM | 0.0293 mL | 0.1464 mL | 0.2928 mL | 0.7321 mL | |
| 100 mM | 0.0234 mL | 0.1171 mL | 0.2343 mL | 0.5857 mL |
CXCR7 antagonist-1 hydrochloride Related Classifications
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