CCR1 antagonist 11 hydrochloride
CCR1 antagonist 11 hydrochloride (A1B1) is an orally active CCR1 antagonist with the IC50 values of 0.03 μM, 0.58 μM and 0.32 μM for hCCR1, mCCR1 and rCCR1, respectively. CCR1 antagonist 11 hydrochloride can be used in the study of rheumatoid arthritis and other related inflammatory diseases.
For research use only. We do not sell to patients.
- Formula: C23H26Cl2FN3O2
- Molecular Weight:466.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.03 μM (hCCR1)，0.58 μM (mCCR1), 0.32 μM (rCCR1)[1].
CCR1 antagonist 11 hydrochloride(A1B1) inhibits MIP-1α-induced Ca2+ mobilization in THP-1 cells with the IC50 value of 1 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Parameters | PO (60 mg/kg) |
| t1/2 (h) | 16.5 |
| Cmax (μM/L) | 0.85 |
| AUC (h*ng/mL) | 784 |
| F (%) | 95 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 466.38
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Formula C23H26Cl2FN3O2
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SMILES
C[C@@H]1CN(CCN1C(/C=C/C2=C(NC(C)=O)C=C(Cl)C=C2)=O)CC3=CC=C(F)C=C3.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CCR1 antagonist 11 hydrochloride Related Classifications
HY-114097A Related Classifications
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