Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis

  • Bioorg Med Chem Lett. 2005 Dec 1;15(23):5160-4. doi: 10.1016/j.bmcl.2005.08.057.
Laszlo Revesz  1 ,  Birgit Bollbuck ,  Thomas Buhl ,  Joerg Eder ,  Ronald Esser ,  Roland Feifel ,  Richard Heng ,  Peter Hiestand ,  Benedicte Jachez-Demange ,  Pius Loetscher ,  Helmut Sparrer ,  Achim Schlapbach ,  Rudolf Waelchli
Affiliations
  • 1. Novartis Institutes for BioMedical Research, Global Discovery Chemistry, Autoimmunity and Transplantation, CH-4002 Basel, Switzerland. [email protected]
PMID: 16198561 DOI: 10.1016/j.bmcl.2005.08.057
Abstract

Cinnamides as novel CCR1 Antagonist chemotypes are described with high affinity to human and rodent receptors. A1B1 and A4B7 showed oral activity in the mouse Collagen induced arthritis.

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