1. NF-κB
    Immunology/Inflammation
  2. NF-κB
    NO Synthase
    COX
    PGE synthase
  3. Ethyl Caffeate

Ethyl Caffeate 

Cat. No.: HY-N6966 Purity: 98.91%
Handling Instructions

Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2) in vitro or in mouse skin.

For research use only. We do not sell to patients.

Ethyl Caffeate Chemical Structure

Ethyl Caffeate Chemical Structure

CAS No. : 102-37-4

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
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25 mg USD 90 In-stock
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50 mg USD 150 In-stock
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100 mg USD 250 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2) in vitro or in mouse skin[1].

IC50 & Target

NF-κB

 

COX-2

 

In Vitro

Ethyl Caffeate markedly suppresses the lipopolysaccharide (LPS)-induced nitric oxide (NO) production with IC50 of 5.5 μg/ml[1].

Molecular Weight

208.21

Formula

C₁₁H₁₂O₄

CAS No.

102-37-4

SMILES

O=C(OCC)/C=C/C1=CC=C(O)C(O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1200.71 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8028 mL 24.0142 mL 48.0284 mL
5 mM 0.9606 mL 4.8028 mL 9.6057 mL
10 mM 0.4803 mL 2.4014 mL 4.8028 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (9.99 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (9.99 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (9.99 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Ethyl CaffeateNF-κBNO SynthaseCOXPGE synthaseNuclear factor-κBNuclear factor-kappaBNitric oxide synthasesNOSCyclooxygenaseProstaglandin E synthaseInhibitorinhibitorinhibit

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Ethyl Caffeate
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HY-N6966
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