Biological activity evaluation and structure-activity relationships analysis of ferulic acid and caffeic acid derivatives for anticancer

  • Bioorg Med Chem Lett. 2012 Oct 1;22(19):6085-8. doi: 10.1016/j.bmcl.2012.08.038.
Weixia Li  1 ,  Nianguang Li ,  Yuping Tang ,  Baoquan Li ,  Li Liu ,  Xu Zhang ,  Haian Fu ,  Jin-Ao Duan
Affiliations
  • 1. Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210046, China.
PMID: 22954735 DOI: 10.1016/j.bmcl.2012.08.038
Abstract

The Anticancer activities of alkyl esters and NO-donors of ferulic acid (FA) and caffeic acid (CA) were assessed by a high-throughout screening (HTS) method, and the structure-activity relationships were described. CA alkyl esters had better Anticancer activities than FA alkyl esters with the same alkyl substituent. Mono-nitrates and phenylfuroxan nitrates were more potent than the dual nitrates. Phenylsulfonylfuroxan nitrates of FA, especially compounds 8b-8d, exhibited more potent activities in Anticancer.