2. GPCR/G Protein
  3. Adenylate Cyclase
  4. AC1-IN-1

AC1-IN-1 

Cat. No.: HY-145830 Purity: 99.81%
COA Handling Instructions

AC1-IN-1 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor with an IC50 of 0.54 µM. AC1-IN-1 displays modest antiallodynic effects in a mouse model of inflammatory pain. AC1-IN-1 has CNS activity.

For research use only. We do not sell to patients.

AC1-IN-1 Chemical Structure

AC1-IN-1 Chemical Structure

CAS No. : 2762422-55-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 528 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 528 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 480 In-stock
Estimated Time of Arrival: December 31
10 mg USD 770 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3850 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

AC1-IN-1 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor with an IC50 of 0.54 µM. AC1-IN-1 displays modest antiallodynic effects in a mouse model of inflammatory pain. AC1-IN-1 has CNS activity[1].

IC50 & Target

IC50: 0.54 µM (AC1)[1]
In Vitro

AC1-IN-1 (compound 38; HEK293 cells; 30 µM, 1 hours) shows nontoxic to this human cell line[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: HEK293 cells
Concentration: 30 µM
Incubation Time: 1 hours
Result: Showed nontoxic to HEK293 cells.
In Vivo

AC1-IN-1 (5.6 mg/kg; i.v.) displays modest, yet statistically significant, antiallodynic effects at 1 h post-treatment compared to the 0 min (allodynic) time point[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female C57BL/6N mice (complete Freund’s adjuvant inflammatory pain model)[1]
Dosage: 5.6 mg/kg (dissolved in 10% DMSO/10% Cremaphor/80% saline)
Administration: Intravenous injection; 2 hours
Result: Displayed modest, yet statistically significant, antiallodynic effects.
Molecular Weight

355.37

Appearance

Solid

Formula

C18H18FN5O2
CAS No.
SMILES

CCC1=CC(NC(N2N=C(C=C2NC(C3=C(C=CC(C)=C3)F)=O)C)=N1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (70.35 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8140 mL 14.0698 mL 28.1397 mL
5 mM 0.5628 mL 2.8140 mL 5.6279 mL
10 mM 0.2814 mL 1.4070 mL 2.8140 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

AC1-IN-12762422-55-7Adenylate CyclaseAdenylyl cyclaseCNS-penetrationHEK293 cellsChronic PainantiallodynicnontoxicInhibitorinhibitorinhibit

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