AC1-IN-1
Based on 1 Customer Validation
AC1-IN-1 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor with an IC50 of 0.54 μM. AC1-IN-1 displays modest antiallodynic effects in a mouse model of inflammatory pain.
For research use only. We do not sell to patients.
- Purity: 99.32%
- CAS No.: 2762422-55-7
- Formula: C18H18FN5O2
- Molecular Weight:355.37
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
GPCR/G Protein Compound Library
HY-L006
-
Heterocyclic Compound Library
HY-L138
-
Membrane Protein-targeted Compound Library
HY-L149
-
Highly Selective Inhibitors Library
HY-L158
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
-
Lactylation Compound Library
HY-L249
Biological Activity
IC50: 0.54 µM (AC1)[1]
AC1-IN-1 (compound 38) (30 μM, 1 h) shows nontoxic to this human cell line in HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HEK293 cells
-
Concentration:30 µM
-
Incubation Time:1 hours
-
Result:Showed nontoxic to HEK293 cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male and female C57BL/6N mice (complete Freund’s adjuvant inflammatory pain model)[1]
-
Dosage:5.6 mg/kg (dissolved in 10% DMSO/10% Cremaphor/80% saline)
-
Administration:Intravenous injection; 2 hours
-
Result:Displayed modest, yet statistically significant, antiallodynic effects.
Chemical Information
-
CAS No. 2762422-55-7
-
Appearance Solid
-
Molecular Weight 355.37
-
Formula C18H18FN5O2
-
Color White to off-white
-
SMILES
CCC1=CC(NC(N2N=C(C=C2NC(C3=C(C=CC(C)=C3)F)=O)C)=N1)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (70.35 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (275 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8140 mL | 14.0698 mL | 28.1397 mL | 70.3492 mL |
| 5 mM | 0.5628 mL | 2.8140 mL | 5.6279 mL | 14.0698 mL | |
| 10 mM | 0.2814 mL | 1.4070 mL | 2.8140 mL | 7.0349 mL | |
| 15 mM | 0.1876 mL | 0.9380 mL | 1.8760 mL | 4.6899 mL | |
| 20 mM | 0.1407 mL | 0.7035 mL | 1.4070 mL | 3.5175 mL | |
| 25 mM | 0.1126 mL | 0.5628 mL | 1.1256 mL | 2.8140 mL | |
| 30 mM | 0.0938 mL | 0.4690 mL | 0.9380 mL | 2.3450 mL | |
| 40 mM | 0.0703 mL | 0.3517 mL | 0.7035 mL | 1.7587 mL | |
| 50 mM | 0.0563 mL | 0.2814 mL | 0.5628 mL | 1.4070 mL | |
| 60 mM | 0.0469 mL | 0.2345 mL | 0.4690 mL | 1.1725 mL |
Powered by Bioz