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Results for "

nontoxic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenylate Cyclase (2) Amyloid-β (7) Antibiotic (2) Apoptosis (3) Aryl Hydrocarbon Receptor (1) Atg4 (1) Autophagy (2) Bacterial (8) BCRP (1) Biochemical Assay Reagents (6) Caspase (2) Cathepsin (1) Cholinesterase (ChE) (2) CMV (1) CRISPR/Cas9 (1) Dengue virus (1) Dynamin (1) Elastase (1) Endogenous Metabolite (3) Flavivirus (1) Fluorescent Dye (7) Fungal (4) Glucocorticoid Receptor (1) Glucosidase (2) Glutathione Peroxidase (1) HCV Protease (1) HSP (1) iGluR (1) IRE1 (1) Isotope-Labeled Compounds (2) Lactate Dehydrogenase (1) Liposome (2) LPL Receptor (1) MALT1 (1) Microtubule/Tubulin (1) nAChR (1) NF-κB (2) P-glycoprotein (1) Parasite (2) Prostaglandin Receptor (1) SARS-CoV (3) STAT (1) Tau Protein (1) Virus Protease (1)
By Research Areas:	Cancer (18) Cardiovascular Disease (3) Endocrinology (1) Infection (17) Inflammation/Immunology (11) Metabolic Disease (7) Neurological Disease (18)

By Targets:

Adenylate Cyclase (2)

Amyloid-β (7)

Antibiotic (2)

Apoptosis (3)

Aryl Hydrocarbon Receptor (1)

Atg4 (1)

Autophagy (2)

Bacterial (8)

BCRP (1)

Biochemical Assay Reagents (6)

Caspase (2)

Cathepsin (1)

Cholinesterase (ChE) (2)

CMV (1)

CRISPR/Cas9 (1)

Dengue virus (1)

Dynamin (1)

Elastase (1)

Endogenous Metabolite (3)

Flavivirus (1)

Fluorescent Dye (7)

Fungal (4)

Glucocorticoid Receptor (1)

Glucosidase (2)

Glutathione Peroxidase (1)

HCV Protease (1)

HSP (1)

iGluR (1)

IRE1 (1)

Isotope-Labeled Compounds (2)

Lactate Dehydrogenase (1)

Liposome (2)

LPL Receptor (1)

MALT1 (1)

Microtubule/Tubulin (1)

nAChR (1)

NF-κB (2)

P-glycoprotein (1)

Parasite (2)

Prostaglandin Receptor (1)

SARS-CoV (3)

STAT (1)

Tau Protein (1)

Virus Protease (1)

By Research Areas:

Cancer (18)

Cardiovascular Disease (3)

Endocrinology (1)

Infection (17)

Inflammation/Immunology (11)

Metabolic Disease (7)

Neurological Disease (18)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D1416

HMBR	Fluorescent Dye	Others
HMBR, an analog bearing an additional methyl group on the aromatic ring, is nonfluorescent by itself, but it fluoresces yellow light upon blue-light excitation when bound to Y-FAST. HMBR is nontoxic for zebrafish embryos. cell-permeant .

HY-N10426

(+)-Cembrene A	Glucosidase	Metabolic Disease
(+)-Cembrene A (Compound 5) is a α-glucosidase inhibitor with an IC₅₀ of 30.31 μM. (+)-Cembrene A is nontoxic towards human normal hepatocyte (LO2) cells .

HY-N10190

Asperaculane B	Parasite Endogenous Metabolite	Infection
Asperaculane B is a fungal metabolite against P. falciparum transmission with an IC₅₀ of 7.89 µM. Asperaculane B also inhibits the development of asexual P. falciparum with IC₅₀ of 3 µM, and it is nontoxic to human cells .

HY-146686

BuChE-IN-3	Cholinesterase (ChE)	Neurological Disease
BuChE-IN-3 (Compound C4) is a potent inhibitor of BuChE with an IC₅₀ of 8.3 nM. BuChE-IN-3 exhibits mild antioxidant capacity, nontoxicity, lipophilicity and neuroprotective activity .

HY-146687

BuChE-IN-4	Cholinesterase (ChE)	Neurological Disease
BuChE-IN-4 (Compound C6) is a potent inhibitor of BuChE with an IC₅₀ of 7.7 nM. BuChE-IN-4 exhibits mild antioxidant capacity, nontoxicity, lipophilicity and neuroprotective activity .

HY-145296

Triflumezopyrim	nAChR	Infection
Triflumezopyrim, a mesoionic insecticide, has high efficiency at a low dosage, and is mainly used to control hopper species. Triflumezopyrim mainly acts on the nicotinic acetylcholine receptor (nAChR) inhibition, which is very highly efficient, rapidly effective, and nearly nontoxic to nontarget arthropods .

HY-W014394

Vanillyl butyl ether	Others	Cardiovascular Disease
Vanillyl butyl ether is a major contributor to the characteristic flavor and fragrance of vanilla. Vanillyl butyl ether is one of the eco-friendly and nontoxic substances. Vanillyl butyl ether has been proposed as a mild warming agent providing a warming sensation and enhancing the blood circulation .

HY-16663

ITX3 2 Publications Verification	Others	Others
ITX3 is a specific and nontoxic inhibitor of TrioN (N-terminal GEF domain of the multidomain Trio protein) with an IC₅₀ value of 76 μM. ITX3 can be used for the research of agent .

HY-N1446A

Glycerol Monoleate	Endogenous Metabolite	Others
Glycerol Monoleate is a nontoxic, biodegradable and biocompatible, lipophilic glycerol fatty acid ester. Glycerol monooleate has hemolytic properties. glycerol monooleate is used as an emulsifier and an absorption enhancer in combination with bile salts. Glycerol Monoleate can be used in drug delivery systems and siRNA delivery in Vitro .

HY-W013435

1,2-Diaminoanthraquinone	Fluorescent Dye	Others
1,2-Diaminoanthraquinone is a sensitivity, specificity and nontoxic nitric oxide (NO) fluorescent probe. 1,2-Diaminoanthraquinone can be used to detect NO productions in live cell and animals with a maximum of absorption at about 540 nm and a detection limit of 5 μM for NO .

HY-107553

Chetomin	HSP Apoptosis	Cancer
Chetomin, an active component of Chaetomium globosum, is a heat shock protein 90/hypoxia-inducible factor 1 alpha (Hsp90/HIF1α) pathway inhibitor. Chetomin is a potent, nontoxic non-small cell lung cancer cancer stem cells (NSCLC CSC)-targeting molecule .

HY-145276

SARS-CoV-2-IN-10	SARS-CoV	Infection
SARS-CoV-2-IN-10 is a potent and nontoxic inhibitor of SARS-CoV-2 3CL protease (3CLpro) with an IC₅₀ and EC₅₀ of 0.13 and 1.03 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals .

HY-145277

SARS-CoV-2-IN-11	SARS-CoV	Infection
SARS-CoV-2-IN-11 is a potent and nontoxic inhibitor of SARS-CoV-2 3CL protease (3CLpro) with an IC₅₀ and EC₅₀ of 0.17 and 1.45 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals .

HY-145080

Dynole 2−24	Dynamin	Neurological Disease
Dynole 2−24 is an indole-based dynamin GTPase inhibitor (IC₅₀=0.56 μM for dynamin I). Dynole 2−24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC_₅₀(CME)=1.9 μM). Dynole 2−24 also shows 4.4-fold selectivity for dynamin I. Dynole 2−24 is active in-cell inhibitor of clathrin-mediated endocytosis . CME: Clathrin mediated endocytosis

HY-100242

Mivotilate

YH439
Aryl Hydrocarbon Receptor Others

Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor (AhR), and acts as a hepatoprotective agent.
HY-111761

DIQ3

Others Cancer

DIQ3 is a potent anti-cancer agent, nontoxic to normal human cell lines .
HY-151888

Anticancer agent 92

Others Cancer

Anticancer agent 92 (Compound 5f) is an anticancer agent that is nontoxic against noncancerous cells .

Mivotilate YH439	Aryl Hydrocarbon Receptor	Others
Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor (AhR), and acts as a hepatoprotective agent.

DIQ3	Others	Cancer
DIQ3 is a potent anti-cancer agent, nontoxic to normal human cell lines .

Anticancer agent 92	Others	Cancer
Anticancer agent 92 (Compound 5f) is an anticancer agent that is nontoxic against noncancerous cells .

HY-101744

Ipsalazide	Autophagy	Inflammation/Immunology
Ipsalazide is a novel sulfasalazine analog designed to release 5-aminosalicylic acid and a nontoxic carrier molecule in the gastrointestinal tract.

HY-N3373

Loganetin	Bacterial	Infection
Loganetin is a non-toxic natural product that may be applied in the antibacterial agent development for treating multidrug-resistant Gram negative infections.

HY-146070

Elastase-IN-1

Elastase Inflammation/Immunology Cancer

Elastase-IN-1 (Compound Q11) is an elastase inhibitor with an IC₅₀ of 0.897 µM. Elastase-IN-1 is non-toxic .
HY-107643

Reversan

CBLC4H10
P-glycoprotein Cancer

Reversan (CBLC4H10) is a potent and nontoxic multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (Pgp) inhibitor .

Elastase-IN-1	Elastase	Inflammation/Immunology Cancer
Elastase-IN-1 (Compound Q11) is an elastase inhibitor with an IC₅₀ of 0.897 µM. Elastase-IN-1 is non-toxic .

Reversan CBLC4H10	P-glycoprotein	Cancer
Reversan (CBLC4H10) is a potent and nontoxic multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (Pgp) inhibitor .

HY-138171

Lipid 5	Biochemical Assay Reagents	Others
Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects .

HY-161021

AC2 selective-IN-1

Adenylate Cyclase Others

AC2 selective-IN-1 (compound 14) is a? potent (IC₅₀=4.45 μM), non-toxic, and selective mAC2 inhibitor .

AC2 selective-IN-1	Adenylate Cyclase	Others
AC2 selective-IN-1 (compound 14) is a? potent (IC₅₀=4.45 μM), non-toxic, and selective mAC2 inhibitor .

HY-128370

Calcium trinatrium diethylenetriaminepentaacetic acid hydrate Ca-DTPA trisodium salt hydrate	CMV	Infection
Calcium trinatrium diethylenetriaminepentaacetic acid hydrate (Ca-DTPA trisodium salt hydrate) is a metal chelator and a useful antidote (such as acute cadmium intoxication). Diethylenetriaminepentaacetic acid calcium trisodium salt hydrate is a nontoxic inhibitor of CMV replication .

HY-132934

Ac32Az19 1 Publications Verification	BCRP	Cancer
Ac32Az19 is a potent, nontoxic, and highly selective BCRP inhibitor with an EC₅₀ value of 13 nM in the BCRP-overexpressed HEK293/R2 cells.

HY-P3307

Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2	Tau Protein	Neurological Disease
Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 is serum stable, non-toxic to neuronal cells, and selectivity inhibits the fibrilization of tau over Aβ₄₂.

HY-146101

NMDA receptor antagonist 5	iGluR	Neurological Disease
NMDA receptor antagonist 5 (Compound 10e) is a potent, brain permeable and non-toxic NMDA receptor antagonist. NMDA receptor antagonist 5 can be used for neurological disorder research .

HY-U00291

Tauroxicum	Antibiotic	Infection
Tauroxicum can be used as a nontoxic, non-antimicrobial agent that can replace or supplement the use of antibiotics in the animal husbandry of livestock animals to increase health and general well-being, productivity, feed efficiency and weight gain.

HY-Y0836

Diethyl succinate Diethyl Butanedioate
Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring .

HY-146427

Antifungal agent 29	Fungal	Infection
Antifungal agent 29 (compound 9d) is a potent, selective and non-toxic antifungal agent. Antifungal agent 29 shows antifungal activity towards Cryptococcus neoformans (MIC ≤ 0.23 μM) .

HY-W010860

Copper(II) Gluconate	Others	Others
Copper(II) Gluconate is a non-toxic copper supplement aid. Copper(II) Gluconate is the copper salt of D-gluconic acid. Copper(II) Gluconate as a precursor catalyst that can be used in the photo-induced polymerisation of acrylates .

HY-N2569

(-)-Curine	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
(-)-Curine is an orally active bisbenzylisoquinoline alkaloid isolated from Chondrodendron platyphyllum. (-)-Curine presents anti-inflammatory and analgesic effects at nontoxic doses, at least in part, resulting from the inhibition of prostaglandin E2 production .

HY-125170

Galiellalactone	STAT	Cancer
Galiellalactone is a is a small non-toxic and non-mutagenic fungal metabolite, a selective inhibitor of STAT3 signaling, with an IC₅₀ of 250-500 nM. Galiellalactone can be used to research castration-resistant prostate cancer .

HY-N5060

Estragole 4-Allylanisole	Parasite	Neurological Disease
Estragole (4-Allylanisole), a relatively nontoxic volatile terpenoid ether, is a major component of the essential oil of many plants. Estragole dose-dependently blocks nerve excitability . Estragole displays anti-toxoplasma activity .

HY-P3417

Amp1EP9	Bacterial	Infection
Amp1EP9 is an antimicrobial peptide. Amp1EP9 is a powerful tool for developing potent and nontoxic antimicrobial agents. Amp1EP9 has the potential for the research of multidrug-resistant bacterial infections .

HY-125870

Gellan gum	Biochemical Assay Reagents	Inflammation/Immunology
Gellan gum is a linear microbial exopolysaccharide that can be used as a cell scaffold for both soft tissue and load bearing applications. Gellan gum has many advantages such as biocompatibility, biodegradability, nontoxic in nature, and physical stability in the presence of cations .

HY-136251

BRD0539	CRISPR/Cas9	Infection
BRD0539 is a cell-permeable and non-toxic inhibitor of CRISPR-Cas9. BRD0539 inhibits Streptococcus pyogenes Cas9 (SpCas9) (apparent IC₅₀=22 μM) in an in vitro DNA cleavage assay .

HY-D0261

Tiron	Biochemical Assay Reagents Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
Tiron is a non-toxic chelator of a variety of metals. Tiron is cell permeable analog of vitamin E and function as hydroxyl radical and superoxide scavenger. Tiron is an orally active antioxidant. Tiron can be used to alleviate acute metal overload in animals .

HY-112711

LV-320	Atg4 Autophagy Cathepsin	Cancer
LV-320 is a potent and uncompetitive ATG4B inhibitor with an IC₅₀ of 24.5 µM and a K_d of 16 µM. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic and active in vivo .

HY-N7393

Isomalt Palatinitol	Lactate Dehydrogenase	Metabolic Disease
Isomalt (Palatinitol), a well-tolerated, non-toxic polyol and a protein-stabilizing excipient, stabilizes lactate dehydrogenase (LDH) moderately during freeze-drying, and performs better during storage. Isomalt is traditionally used as a sweetening agent in the food industry and as a tabletting excipient for pharmaceutical purposes .

HY-N6595

Lucidone A	Others	Others
Lucidone A is a lanostanoid isolated from the fruiting bodies of G. resinaceum. lucidone A showed inhibitory effects against the increase of ALT and AST levels in HepG2 cells induced by H2O2 compared to a control group in the range of their maximum non-toxic concentration (MNTC) .

HY-145830

AC1-IN-1	Adenylate Cyclase	Neurological Disease
AC1-IN-1 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor with an IC₅₀ of 0.54 µM. AC1-IN-1 displays modest antiallodynic effects in a mouse model of inflammatory pain. AC1-IN-1 has CNS activity .

HY-B2144A

Chitosan (MW 150000) 2 Publications Verification Deacetylated chitin (MW 150000); Poly(D-glucosamine) (MW 150000)	Bacterial Fungal	Infection Cancer
Chitosan (MW 150000) (Deacetylated chitin (MW 150000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 150000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities .

HY-B2144B

Chitosan (MW 30000) 1 Publications Verification Deacetylated chitin (MW 30000); Poly(D-glucosamine) (MW 30000)	Bacterial Fungal	Infection Cancer
Chitosan (MW 30000) (Deacetylated chitin (MW 30000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 30000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities .

HY-141613

1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium DOPS-NA	Liposome	Others
1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium is a ubstitute for Phosphoserine/phosphatidylserine. 1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium can be used in lipid mixtures with DOPC and DOPE as effective nontoxic and nonviral DNA vectors .

HY-D1623

Cyanine3 carboxylic acid chloride	Fluorescent Dye	Others
Cyanine3 carboxylic acid chloride is a non-toxic red fluorescent dye with good solubility in organic solvents. Cyanine3 carboxylic acid chloride can be used as a non-reactive fluorophore for experimental control and calibration. Cyanine3 carboxylic acid chloride can also be synthesized with targeted agents as fluorescent probes for rapid detection of agent reactions .

HY-Y0836S1

Diethyl succinate-d4 Diethyl Butanedioate-d₄	Isotope-Labeled Compounds	Metabolic Disease
Diethyl succinate-d₄ is the deuterium labeled Diethyl succinate[1]. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring[2].

HY-W010041

Scyllo-Inositol	Amyloid-β Endogenous Metabolite	Neurological Disease
Scyllo-Inositol, an amyloid inhibitor, potentialy inhibits α-synuclein aggregation. Scyllo-Inositol stabilizes a non-fibrillar non-toxic form of amyloid-β peptide (Aβ42) in vitro, reverses cognitive deficits, and reduces synaptic toxicity and lowers amyloid plaques in an Alzheimer's disease mouse model .

HY-Y0836S

Diethyl succinate-13C4 1,4-Diethyl butanedioate-1,2,3,4-¹³C₄	Isotope-Labeled Compounds	Metabolic Disease
Diethyl succinate- ¹³C₄ is the ¹³C labeled Diethyl succinate[1]. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring[2].

HY-155720

Mtb-IN-4	Bacterial	Infection
Mtb-IN-4 (compound 17h) is a nontoxic isoxazole, with anti-Mycobacterium tuberculosis (Mtb) activity (IC₅₀=0.70 μM). Mtb-IN-4 inhibits Mtb respiration and biofilm formation in macrophage, and enhances antibiotic isoniazid (INH) inhibition against INH-resistant Mtb mutant .

Cat. No.	Product Name	Type

HY-D1416

HMBR	Fluorescent Dyes/Probes
HMBR, an analog bearing an additional methyl group on the aromatic ring, is nonfluorescent by itself, but it fluoresces yellow light upon blue-light excitation when bound to Y-FAST. HMBR is nontoxic for zebrafish embryos. cell-permeant .

HY-W013435

1,2-Diaminoanthraquinone	Fluorescent Dyes/Probes
1,2-Diaminoanthraquinone is a sensitivity, specificity and nontoxic nitric oxide (NO) fluorescent probe. 1,2-Diaminoanthraquinone can be used to detect NO productions in live cell and animals with a maximum of absorption at about 540 nm and a detection limit of 5 μM for NO .

HY-D1297

ER-Tracker Green

Fluorescent Dyes/Probes

ER-Tracker dye is a derivative of BODIPY series dyes coupled with Glibenclamide (HY-15206), highly selective binding to the endoplasmic reticulum, non-toxic to cells at low concentrations, this type of dye is an environmentally sensitive probe, and formaldehyde treatment can still retain part of the fluorescence, with high fluorescence life, good extinction coefficient and other characteristics. Glibenclamide is an atp-dependent K ⁺ channel blocker (Kir6, KATP) and CFTR Cl-channel blocker that binds in the endoplasmic reticulum. ER-Tracker is not suitable for staining cells after fixation .

HY-D1623

Cyanine3 carboxylic acid chloride	Fluorescent Dyes/Probes
Cyanine3 carboxylic acid chloride is a non-toxic red fluorescent dye with good solubility in organic solvents. Cyanine3 carboxylic acid chloride can be used as a non-reactive fluorophore for experimental control and calibration. Cyanine3 carboxylic acid chloride can also be synthesized with targeted agents as fluorescent probes for rapid detection of agent reactions .

HY-118540

Resazurin

Diazoresorcinol

Fluorescent Dyes/Probes

Resazurin (Diazoresorcinol) is a water-soluble, non-toxic, stable, membrane-permeable blue non-fluorescent dye (faintly fluorescent). Resazurin is used as a redox indicator, can be reduced to pink, highly fluorescent Resorufin (Ex=530-560 nm, Em=590 nm) in living cells. Resazurin can be used for the detection of cell viability, toxicity, proliferation, migration and invasion in cells (human, plant and animal, bacterial and fungal) .

HY-D1429

ER-Tracker Blue-White DPX

Fluorescent Dyes/Probes

HY-D1431

ER-Tracker Red

Fluorescent Dyes/Probes

Cat. No.	Product Name	Type

HY-138171

Lipid 5

Drug Delivery

Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects .

HY-141613

1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium DOPS-NA	Drug Delivery
1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium is a ubstitute for Phosphoserine/phosphatidylserine. 1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium can be used in lipid mixtures with DOPC and DOPE as effective nontoxic and nonviral DNA vectors .

HY-W130177

Iodocholine iodide	Biochemical Assay Reagents
Iodocholine iodide is a non-toxic, metabolizable "green" catalyst that can catalyze the free radical polymerization of functional polymers. Iodocholine iodide is also the non-radioactive iodide of Carbon-11 choline. C-11 Choline can be used in PET imaging and non-informative bone scintigraphy, CT or MRI to monitor various types of cancer .

HY-112758

DLin-KC2-DMA 4 Publications Verification	Drug Delivery
DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies .

HY-125870

Gellan gum	Biochemical Assay Reagents
Gellan gum is a linear microbial exopolysaccharide that can be used as a cell scaffold for both soft tissue and load bearing applications. Gellan gum has many advantages such as biocompatibility, biodegradability, nontoxic in nature, and physical stability in the presence of cations .

HY-D1005

Poloxamer 407 (F127) 2 Publications Verification PEG-PPG-PEG, 12600 (Average Mn)	Biochemical Assay Reagents
Poloxamer 407 (F127) is a nonionic surfactant that is 100% active and relatively non-toxic to cells at low concentrations, and frequently used with dye AM esters such as Indo-1 AM, Fura-2 AM, Calcein AM, Fluo-3 AM, Fluo-4 AM, Quest Fluo-8™ AM and Quest Rhod-4™ AM, etc. to improve their water solubility. Poloxamer 407 is also a lipoprotein lipase inhibitor .

HY-W250127

Disodium terephthalate

Terephthalic acid disodium salt

Biochemical Assay Reagents

Disodium terephthalate belongs to the class of organic salts. It is commonly used as a catalyst or intermediate in the production of a variety of industrial and consumer products, including polyethylene terephthalate (PET) plastics, polyester fibers and films. Disodium terephthalate has excellent thermal stability, chemical resistance and mechanical properties, making it ideal for high performance applications. Additionally, it is non-toxic, non-flammable and environmentally friendly, making it an attractive alternative to other petroleum-based chemicals. In the food and pharmaceutical industries, Disodium terephthalate is used as a pH regulator and buffer. It is generally considered safe for use in food and pharmaceutical applications by regulatory agencies such as the FDA.

Cat. No.	Product Name	Target	Research Area

HY-P0033

Argireline Acetyl hexapeptide-3	Peptides	Neurological Disease
Argireline (Acetyl hexapeptide-3) is a non-toxic, skin-permeable, antiwrinkle peptide. Argireline significantly inhibits Ca ²⁺ dependent neurotransmitter release (acetylcholine) at the neuromuscular junction. Argireline has antiwrinkle and anti-aging activity .

HY-P5361

β-Amyloid (40-1)

Peptides Others

β-Amyloid (40-1) is a biological active peptide. (non-toxic reverse fragment Aβ(40–1), control of HY-P0265)

HY-P3307

Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2	Tau Protein	Neurological Disease
Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 is serum stable, non-toxic to neuronal cells, and selectivity inhibits the fibrilization of tau over Aβ₄₂.

HY-P3417

Amp1EP9	Bacterial	Infection
Amp1EP9 is an antimicrobial peptide. Amp1EP9 is a powerful tool for developing potent and nontoxic antimicrobial agents. Amp1EP9 has the potential for the research of multidrug-resistant bacterial infections .

HY-P0033A

Argireline acetate Acetyl hexapeptide-3 acetate	Peptides	Neurological Disease
Argireline acetate (Acetyl hexapeptide-3 acetate) is a non-toxic, skin-permeable, antiwrinkle peptide. Argireline acetate significantly inhibits Ca ²⁺ dependent neurotransmitter release (acetylcholine) at the neuromuscular junction. Argireline acetate has antiwrinkle and anti-aging activity .

HY-P4900

Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone	Caspase	Others
Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone is a cell-permeable, non-toxic inhibitor that binds irreversibly to activated caspase-3 in apoptotic cells. The fluorescence intensity can be measured by flow cytometry, microwell plate reader, or fluorescence microscopy .

HY-P5486

Tet-20	Bacterial	Others
Tet-20 is a biological active peptide. (Tet-20, is a synthetic cathelicidin-derived peptide. It was tested as infection-resistant coating for medical devices. When tethered on an implant surface Tet-20 exhibited broad antimicrobial activities both in vivo and in vitro. It can stop biofilm formation and appears to be non-toxic to eukaryotic cells)

HY-P1629

Temporin A	Bacterial Fungal Antibiotic	Infection
Temporin A is a short alpha-helical antimicrobial peptide isolated from the skin of the frog Rana temporaria. Temporin A is effective against a broad spectrum of Gram-positive bacteria. Temporin A interacts directly with the cell membrane of the microorganism and it is non-toxic to erythrocytes at concentrations that are antimicrobial. Temporin A also has antifungal activities (against yeast-like Candida albicans) .

HY-105066

Davunetide	Microtubule/Tubulin Amyloid-β	Neurological Disease
Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity .

HY-P1940

Maculosin Cyclo(Tyr-Pro)	Peptides	Cancer
Maculosin is a host-specific phytotoxin for spotted knapweed from Alternaria alternata. Maculosin is a quorum-sensing molecule involved in cell-cell communication by Pseudomonas aeruginosa. Maculosin also acts as a signaling molecule regulating virulence gene expression in Lactobacillus reuteri. Maculosin shows antioxidant, anti-cancer and non-toxicity properties. Maculosin shows cytotoxic activity against the human liver cancer cell lines, with an IC₅₀ of 48.90 µg/mL .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W014394

Vanillyl butyl ether	Cardiovascular Disease Monophenols other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields	Others
Vanillyl butyl ether is a major contributor to the characteristic flavor and fragrance of vanilla. Vanillyl butyl ether is one of the eco-friendly and nontoxic substances. Vanillyl butyl ether has been proposed as a mild warming agent providing a warming sensation and enhancing the blood circulation .

HY-N3373

Loganetin	Infection Structural Classification Human Gut Microbiota Metabolites Iridoids Classification of Application Fields Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants Endogenous metabolite Disease Research Fields	Bacterial
Loganetin is a non-toxic natural product that may be applied in the antibacterial agent development for treating multidrug-resistant Gram negative infections.

HY-N10426

(+)-Cembrene A	Structural Classification Animals Terpenoids Source classification	Glucosidase
(+)-Cembrene A (Compound 5) is a α-glucosidase inhibitor with an IC₅₀ of 30.31 μM. (+)-Cembrene A is nontoxic towards human normal hepatocyte (LO2) cells .

HY-N10190

Asperaculane B	Infection Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Endogenous metabolite Disease Research Fields	Parasite Endogenous Metabolite
Asperaculane B is a fungal metabolite against P. falciparum transmission with an IC₅₀ of 7.89 µM. Asperaculane B also inhibits the development of asexual P. falciparum with IC₅₀ of 3 µM, and it is nontoxic to human cells .

HY-N1446A

Glycerol Monoleate	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Glycerol Monoleate is a nontoxic, biodegradable and biocompatible, lipophilic glycerol fatty acid ester. Glycerol monooleate has hemolytic properties. glycerol monooleate is used as an emulsifier and an absorption enhancer in combination with bile salts. Glycerol Monoleate can be used in drug delivery systems and siRNA delivery in Vitro .

HY-N2569

(-)-Curine	Alkaloids Structural Classification Classification of Application Fields Source classification Stephania epigaea Lo Phenols Polyphenols Quinoline Alkaloids Plants Disease Research Fields Menispermaceae Endocrinology	Prostaglandin Receptor
(-)-Curine is an orally active bisbenzylisoquinoline alkaloid isolated from Chondrodendron platyphyllum. (-)-Curine presents anti-inflammatory and analgesic effects at nontoxic doses, at least in part, resulting from the inhibition of prostaglandin E2 production .

HY-N5060

Estragole 4-Allylanisole	Structural Classification Pandanus amaryllifolius Roxb. Simple Phenylpropanols Source classification Phenylpropanoids Plants Pandanaceae	Parasite
Estragole (4-Allylanisole), a relatively nontoxic volatile terpenoid ether, is a major component of the essential oil of many plants. Estragole dose-dependently blocks nerve excitability . Estragole displays anti-toxoplasma activity .

HY-N7393

Isomalt Palatinitol	other families Source classification Metabolic Disease Plants Disease Research Fields Saccharides	Lactate Dehydrogenase
Isomalt (Palatinitol), a well-tolerated, non-toxic polyol and a protein-stabilizing excipient, stabilizes lactate dehydrogenase (LDH) moderately during freeze-drying, and performs better during storage. Isomalt is traditionally used as a sweetening agent in the food industry and as a tabletting excipient for pharmaceutical purposes .

HY-N6595

Lucidone A	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Others
Lucidone A is a lanostanoid isolated from the fruiting bodies of G. resinaceum. lucidone A showed inhibitory effects against the increase of ALT and AST levels in HepG2 cells induced by H2O2 compared to a control group in the range of their maximum non-toxic concentration (MNTC) .

HY-W010041

Scyllo-Inositol	Structural Classification Natural Products Source classification Endogenous metabolite	Amyloid-β Endogenous Metabolite
Scyllo-Inositol, an amyloid inhibitor, potentialy inhibits α-synuclein aggregation. Scyllo-Inositol stabilizes a non-fibrillar non-toxic form of amyloid-β peptide (Aβ42) in vitro, reverses cognitive deficits, and reduces synaptic toxicity and lowers amyloid plaques in an Alzheimer's disease mouse model .

HY-14621

Zingerone 2 Publications Verification Vanillylacetone; Gingerone	Zingiber officinale Roscoe Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Metabolic Disease Plants Disease Research Fields Inflammation/Immunology Zingiberaceae	NF-κB
Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor properties . Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways . Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells .

HY-N2132

Flavokawain B 1 Publications Verification Flavokavain B	Flavonoids Chalcones Monophenols other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields Cancer	Apoptosis
Flavokawain B (Flavokavain B) is a chalcone isolated from the root extracts of kava-kava plant and a potent apoptosis inducer for inhibiting the growth of various cancer cell lines. Flavokawain B (Flavokavain B) shows strong antiangiogenic activity. Flavokawain B (Flavokavain B) inhibits human brain endothelial cell (HUVEC) migration and tube formation with very low and non-toxic concentrations .

HY-P1940

Maculosin Cyclo(Tyr-Pro)	Alkaloids Monophenols Microorganisms Pyrrole Alkaloids Source classification Phenols Disease Research Fields Cancer	Others
Maculosin is a host-specific phytotoxin for spotted knapweed from Alternaria alternata. Maculosin is a quorum-sensing molecule involved in cell-cell communication by Pseudomonas aeruginosa. Maculosin also acts as a signaling molecule regulating virulence gene expression in Lactobacillus reuteri. Maculosin shows antioxidant, anti-cancer and non-toxicity properties. Maculosin shows cytotoxic activity against the human liver cancer cell lines, with an IC₅₀ of 48.90 µg/mL .

Cat. No.	Product Name	Chemical Structure

HY-Y0836S

Diethyl succinate-13C4
Diethyl succinate- ¹³C₄ is the ¹³C labeled Diethyl succinate[1]. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring[2].

HY-Y0836S1

Diethyl succinate-d4
Diethyl succinate-d₄ is the deuterium labeled Diethyl succinate[1]. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring[2].

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