2. Anti-infection
  3. SARS-CoV
  4. SARS-CoV-2-IN-11

SARS-CoV-2-IN-11 is a potent and nontoxic inhibitor of SARS-CoV-2 3CL protease (3CLpro) with an IC50 and EC50 of 0.17 and 1.45 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals.

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SARS-CoV-2-IN-11

SARS-CoV-2-IN-11 Chemical Structure

CAS No. : 2722635-28-9

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SARS-CoV-2-IN-11 Related Antibodies

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Description

SARS-CoV-2-IN-11 is a potent and nontoxic inhibitor of SARS-CoV-2 3CL protease (3CLpro) with an IC50 and EC50 of 0.17 and 1.45 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals[1].

IC50 & Target

SARS-CoV-2 3C-like protease[1]
Cellular Effect
Cell Line Type Value Description References
HEK-293T CC50
> 100 μM
Compound: 15c
Cytotoxicity against HEK293T cells assessed as reduction in cell viability measured after 72 hrs by CytoTox 96 nonradioactive cytotoxicity assay
Cytotoxicity against HEK293T cells assessed as reduction in cell viability measured after 72 hrs by CytoTox 96 nonradioactive cytotoxicity assay
[PMID: 34865476]
Vero EC50
0.7 μM
Compound: 15c
Antiviral activity against SARS CoV-2 infected in African green monkey Vero cells assessed as inhibition of viral replication incubated for 48 to 72 hrs by plaque reduction assay
Antiviral activity against SARS CoV-2 infected in African green monkey Vero cells assessed as inhibition of viral replication incubated for 48 to 72 hrs by plaque reduction assay
[PMID: 34865476]
Molecular Weight

625.66

Formula

C27H38F2N3NaO8S
CAS No.
SMILES

O=C(NCC1)[C@@H]1C[C@@H](C(O)S(=O)(O[Na])=O)NC([C@H](CC(C)C)NC(OC(C2=CC=CC=C2)C3CCC(F)(CC3)F)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SARS-CoV-2-IN-11 Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARS-CoV-2-IN-112722635-28-9SARS-CoVSARS coronavirusnontoxicSARS-CoV-2 3CL protease3CLproantiviralInhibitorinhibitorinhibit

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