1. Immunology/Inflammation
  2. Aryl Hydrocarbon Receptor
  3. Mivotilate

Mivotilate (Synonyms: YH439)

Cat. No.: HY-100242 Purity: >98.0%
Handling Instructions

Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor (AhR), and acts as a hepatoprotective agent.

For research use only. We do not sell to patients.

Mivotilate Chemical Structure

Mivotilate Chemical Structure

CAS No. : 130112-42-4

Size Price Stock Quantity
1 mg USD 150 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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  • Biological Activity

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Description

Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor (AhR), and acts as a hepatoprotective agent.

IC50 & Target

Aryl hydrocarbon receptor[1]

In Vitro

Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor. Mivotilate (YH439) has a novel activation mode that tolerates mutation of histidine 285 to tyrosine[1]. Mivotilate induces cytochromes P4501A1/2 (CYP1A1/2) through the aryl hydrocarbon (Ah) receptor[3].

In Vivo

Mivotilate (YH439, 150 mg/kg, p.o.) reduces CYP2E1-mediated NDMA demethylase activity in rats, but shows no obvious effect on NADPH-dependent P450 oxidoreductase activity. Mivotilate (75-300 mg/kg) rapidly decreases immunoreactive CYP2E1 protein. Mivotilate (150 mg/kg, p.o.) inhibits the transcription of CYP2E1 in rats[2].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
Animal Administration
[2]

Male outbred Sprague-Dawley rats (weighing 100-150 g) are kept on a 12-h light-dark cycle with NIH 31 autoclavable rat die and water ad libitum. After a single oral administration of Mivotilate (75, 150, and 300 mg/kg body wt, diluted in corn oil), the animals are sacrificed at different times as indicated. Livers from control (corn oil-treated), starved (2 days) and Mivotilate-treated animals (n = 5 per group) are immediately excised, freeze-clamped, and processed further. Another group of rats (n = 3) is treated with phenobarbital (100 mg/kg/day) by intraperitoneal injection for 2 days and sacrificed 24 h after the last dose[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

330.45

Formula

C₁₂H₁₄N₂O₃S₃

CAS No.

130112-42-4

SMILES

O=C(OC(C)C)/C(C(NC1=NC(C)=CS1)=O)=C2SCS\2

Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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Product Name:
Mivotilate
Cat. No.:
HY-100242
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Mivotilate

Cat. No.: HY-100242