2. Anti-infection
  3. SARS-CoV Virus Protease
  4. SP inhibitor 1

SP inhibitor 1 (compound 34) is a selective SARS-CoV-2 spike protein (SP) inhibitor with an IC50 of 3.26 μM, >25 μM, >25 μM for SP, Mpro and PLpro protein, respectively. SP inhibitor 1 is a vitro SARS-CoV-2 replication inhibitor at non-toxic concentrations (0.3250<5.98 μM). SP inhibitor 1 shows cellular antiviral activity.

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SP inhibitor 1

SP inhibitor 1 Chemical Structure

CAS No. : 2766185-81-1

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SP inhibitor 1 Related Antibodies

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Description

SP inhibitor 1 (compound 34) is a selective SARS-CoV-2 spike protein (SP) inhibitor with an IC50 of 3.26 μM, >25 μM, >25 μM for SP, Mpro and PLpro protein, respectively. SP inhibitor 1 is a vitro SARS-CoV-2 replication inhibitor at non-toxic concentrations (0.3250<5.98 μM). SP inhibitor 1 shows cellular antiviral activity[1].

Cellular Effect
Cell Line Type Value Description References
Vero CC50
31.53 μM
Compound: 34
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by coulter counter method
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by coulter counter method
[PMID: 34571172]
Vero EC50
0.44 μM
Compound: 34
Antiviral activity against Severe acute respiratory syndrome coronavirus 2 UC-1075 infected in African green monkey Vero cells assessed as reduction in plaque formation measured after 5 days by microscopic analysis
Antiviral activity against Severe acute respiratory syndrome coronavirus 2 UC-1075 infected in African green monkey Vero cells assessed as reduction in plaque formation measured after 5 days by microscopic analysis
[PMID: 34571172]
Molecular Weight

530.70

Formula

C36H38N2O2
CAS No.
SMILES

COC(C1=CC=C2C(C(CN(CC3=CC=CC=C3)CCC4=CC=C(C=C4)C5=CC=CC=C5)=CN2CC(C)C)=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SP inhibitor 1 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SP inhibitor 12766185-81-1SP inhibitor1SP inhibitor-1SARS-CoVVirus ProteaseSARS coronavirusSARS-CoV-2spike proteinSPMproPLproreplicationantiviral activityInhibitorinhibitorinhibit

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