1. Anti-infection
    Metabolic Enzyme/Protease
  2. HCV Protease
  3. HZ-1157

HZ-1157 

Cat. No.: HY-109571
Handling Instructions

HZ-1157 inhibits HCV NS3/4A protease with an IC50 of 1.0 μmol/L. HZ-1157 (4a) has a high dengue virus inhibitory activity (EC50 = 0.15 μM) and is a relatively nontoxic (CC50 > 10 μM) dengue antiviral agent.

For research use only. We do not sell to patients.

HZ-1157 Chemical Structure

HZ-1157 Chemical Structure

CAS No. : 1009734-33-1

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Description

HZ-1157 inhibits HCV NS3/4A protease with an IC50 of 1.0 μmol/L. HZ-1157 (4a) has a high dengue virus inhibitory activity (EC50 = 0.15 μM) and is a relatively nontoxic (CC50 > 10 μM) dengue antiviral agent[1][2].

IC50 & Target

IC50: 1.0 μmol/L (HCV NS3/4A protease)[2].

In Vitro

HZ-1157 (4a) is known to possess a broad spectrum of biological activities, such as protein lysine methyltransferase G9a inhibition, SMN2 promoter activation, dihydrofolate reductase inhibition, and others[1][2].

Cell Viability Assay[2].

Cell Line: HZ-1157 (4a) is known to possess a broad spectrum of biological activities, such as protein lysine methyltransferase G9a inhibition, SMN2 promoter activation, dihydrofolate reductase inhibition, and others.
Concentration: 0-10 μmol/L.
Incubation Time: 72 h.
Result: Inhibited HCV infection in vitro with an IC50 of 0.82 μmol/L.
Molecular Weight

232.28

Formula

C₁₂H₁₆N₄O

CAS No.

1009734-33-1

SMILES

NC1=NC(N)=C2C(OC(C)(C)C)=CC=CC2=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

HZ-1157HZ1157HZ 1157HCV ProteasedenguevirusHCVInhibitorinhibitorinhibit

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