1009734-33-1
1009734-33-1
Chemical Structure
HZ-1157
- CAS No.: 1009734-33-1
- Formula:C12H16N4O
- Molecular Weight:232.28
IUPAC Name: 5-(tert-butoxy)quinazoline-2,4-diamine
InChIKey: JQHKDYFLRJIBLX-UHFFFAOYSA-N
SMILES: NC1=NC(N)=C2C(OC(C)(C)C)=CC=CC2=N1
Biological Activity: HZ-1157 inhibits HCV NS3/4A protease with an IC50 of 1.0 μmol/L. HZ-1157 (4a) has a high dengue virus inhibitory activity (EC50 = 0.15 μM) and is a relatively nontoxic (CC50 > 10 μM) dengue antiviral agent[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HZ-1157 | 98.16% | HZ-1157 inhibits HCV NS3/4A protease with an IC50 of 1.0 μmol/L. HZ-1157 (4a) has a high dengue virus inhibitory activity (EC50 = 0.15 μM) and is a relatively nontoxic (CC50 > 10 μM) dengue antiviral agent. | ||||||||||||||||||||
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References
- [1]. Ye Yu, et al. Discovering Novel anti-HCV Compounds With Inhibitory Activities Toward HCV NS3/4A Protease. Acta Pharmacol Sin. 2014 Aug;35(8):1074-81. [Content Brief]
- [2]. Bo Chao, et al. Discovery and Optimization of 2,4-diaminoquinazoline Derivatives as a New Class of Potent Dengue Virus Inhibitors. J Med Chem . 2012 Apr 12;55(7):3135-43. [Content Brief]
Keywords
