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Zingerone  (Synonyms: Vanillylacetone; Gingerone)

Cat. No.: HY-14621 Purity: 99.77%
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Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor properties. Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways. Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells. Zingerone can cross the blood-brain barrier (BBB).

For research use only. We do not sell to patients.

CAS No. : 122-48-5

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of Zingerone:

Zingerone Related Antibodies

Top Publications Citing Use of Products

    Zingerone purchased from MedChemExpress. Usage Cited in: Curr Issues Mol Biol. 2025 Nov 19;47(11):963.  [Abstract]

    Zingerone demonstrated no cytotoxicity toward BMMCs and RBL-2H3 cells after 8 h of incubation across concentrations of 1–50 μM, as quantified by CCK-8 assays.

    Zingerone purchased from MedChemExpress. Usage Cited in: Curr Issues Mol Biol. 2025 Nov 19;47(11):963.  [Abstract]

    IgE-sensitized BMMCs were pretreated with graded Zingerone concentrations (10, 20 μM, 2 h) followed by DNP-HSA (Ag) stimulation (15 min–8 h). Immunoblotting of cell lysates demonstrated dose-dependent inhibition of FcεRI-proximal signaling phosphoproteins.

    Zingerone purchased from MedChemExpress. Usage Cited in: Curr Issues Mol Biol. 2025 Nov 19;47(11):963.  [Abstract]

    Zingerone (10, 20 μM) improves AMPK enucleation by mast cell activation by immunofluorescence staining.

    Zingerone purchased from MedChemExpress. Usage Cited in: Curr Issues Mol Biol. 2025 Nov 19;47(11):963.  [Abstract]

    Ear tissue dye extravasation was quantified after 1 h by formamide extraction at 63 °C overnight and quantified by absorbance at 630 nm treated with Zingerone (25 or 50 mg/kg, p.o.).

    Zingerone purchased from MedChemExpress. Usage Cited in: Saudi J Biol Sci. 2023 Oct;30(10):103775.

    Photomicrographs were taken from control and Zingerone (100 mg/kg, p.o.)-treated animals and demonstrated normal duodenal histology of the epithelia with obvious intact microvilli (long arrow) at the top of the mucosa, goblet cells (short arrow), and intestinal crypts (arrowhead).

    View All NF-κB Isoform Specific Products:

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    NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor[3] properties[1]. Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways[2]. Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells[3]. Zingerone can cross the blood-brain barrier (BBB)[4].

    IC50 & Target

    NF-κB[3]
    Cellular Effect
    Cell Line Type Value Description References
    B16 IC50
    > 100 μM
    Compound: 9
    Inhibition of melanogenesis in theophylline-stimulated mouse B16-4A5 cells after 72 hrs
    Inhibition of melanogenesis in theophylline-stimulated mouse B16-4A5 cells after 72 hrs
    		[PMID: 19615910]
    B16-4A5 IC50
    > 100 μM
    Compound: 9
    Inhibition of theophylline-stimulated mouse B16-4A5 cell proliferation assessed as cell viability after 68 hrs by WST8 assay
    Inhibition of theophylline-stimulated mouse B16-4A5 cell proliferation assessed as cell viability after 68 hrs by WST8 assay
    		[PMID: 19615910]
    IMR-32 ED50
    > 129 μM
    Compound: 3
    Effective dose to protect IMR-32 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay
    Effective dose to protect IMR-32 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay
    		[PMID: 14980683]
    PC-12 ED50
    > 129 μM
    Compound: 3
    Effective dose to protect PC12 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay
    Effective dose to protect PC12 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay
    		[PMID: 14980683]
    In Vitro

    Zingerone is a nontoxic methoxyphenol with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic properties[1].
    Zingerone (0-2 mM) decreases neruoblastoma cell survival[3].
    Zingerone (0-2 mM) reduces cyclin D1 expression, increases cleavage of caspase-3 and PARP-1 in BE(2)-M17 cells[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Zingerone Related Antibodies
    In Vivo

    Zingerone (50, 100 mg/kg, p.o. daily for 21 days) protects against alloxan-induced diabetes via alleviation of oxidative stress and inflammation in rat[2].
    Zingerone (10 mg/kg, i.p.) inhibits tumor progression through mitotic arrest, failure of cell division, and stimulation of apoptosis[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    194.23

    Formula

    C11H14O3
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    COC1=C(O)C=CC(CCC(C)=O)=C1
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (514.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.1485 mL 25.7427 mL 51.4854 mL
    5 mM 1.0297 mL 5.1485 mL 10.2971 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (12.87 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (12.87 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.77%

    SDS (394 KB)

    COA (245 KB) HNMR (245 KB) RP-HPLC (246 KB) MS (67 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 5.1485 mL 25.7427 mL 51.4854 mL 128.7134 mL
    5 mM 1.0297 mL 5.1485 mL 10.2971 mL 25.7427 mL
    10 mM 0.5149 mL 2.5743 mL 5.1485 mL 12.8713 mL
    15 mM 0.3432 mL 1.7162 mL 3.4324 mL 8.5809 mL
    20 mM 0.2574 mL 1.2871 mL 2.5743 mL 6.4357 mL
    25 mM 0.2059 mL 1.0297 mL 2.0594 mL 5.1485 mL
    30 mM 0.1716 mL 0.8581 mL 1.7162 mL 4.2904 mL
    40 mM 0.1287 mL 0.6436 mL 1.2871 mL 3.2178 mL
    50 mM 0.1030 mL 0.5149 mL 1.0297 mL 2.5743 mL
    60 mM 0.0858 mL 0.4290 mL 0.8581 mL 2.1452 mL
    80 mM 0.0644 mL 0.3218 mL 0.6436 mL 1.6089 mL
    100 mM 0.0515 mL 0.2574 mL 0.5149 mL 1.2871 mL
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    Zingerone Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Zingerone122-48-5Vanillylacetone GingeroneNF-κBEnvironmental PollutantsNuclear factor-κBNuclear factor-kappaBEnvironmental ContaminantsInhibitorinhibitorinhibit

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