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  4. Lipid 5

Lipid 5 

Cat. No.: HY-138171
Handling Instructions

Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects.

For research use only. We do not sell to patients.

Lipid 5 Chemical Structure

Lipid 5 Chemical Structure

CAS No. : 2089251-33-0

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25 mg USD 650 In-stock
50 mg USD 1150 In-stock
100 mg USD 1900 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects[1].

In Vitro

Replacement of the linoleic tail with a primary ester-containing lipid tail (Lipid 5) provids increased expression and optimal tissue clearance. The metabolite identification studies with Lipid 5 indicated that hydrolysis of the primary ester is the first step in the metabolism of the lipid[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Clearance of Lipid 5 and MC3 from multiple mouse tissues is measured after dosing 0.05 mg/kg mRNA on days 1, 8, and 15 in CD-1 female mice. Liver and spleen have the highest levels of Lipid 5, however, significantly lower levels than MC3. Lipid 5 is detected in plasma, lung, and kidney, but not in heart[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

710.17

Appearance

Liquid

Formula

C44H87NO5
CAS No.
SMILES

O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCO)CCCCCCCC(OCCCCCCCCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (140.81 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4081 mL 7.0406 mL 14.0811 mL
5 mM 0.2816 mL 1.4081 mL 2.8162 mL
10 mM 0.1408 mL 0.7041 mL 1.4081 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (3.52 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (3.52 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.52 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Keywords:

Lipid 52089251-33-0Lipid5Lipid-5Biochemical Assay ReagentsmRNAaminolipidprimaryInhibitorinhibitorinhibit

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