1. Biochemical Assay Reagents
  2. Lipid 5

Lipid 5 

Cat. No.: HY-138171
Handling Instructions

Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects.

For research use only. We do not sell to patients.

Lipid 5 Chemical Structure

Lipid 5 Chemical Structure

CAS No. : 2089251-33-0

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Description

Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects[1].

In Vitro

Replacement of the linoleic tail with a primary ester-containing lipid tail (Lipid 5) provids increased expression and optimal tissue clearance. The metabolite identification studies with Lipid 5 indicated that hydrolysis of the primary ester is the first step in the metabolism of the lipid[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Clearance of Lipid 5 and MC3 from multiple mouse tissues is measured after dosing 0.05 mg/kg mRNA on days 1, 8, and 15 in CD-1 female mice. Liver and spleen have the highest levels of Lipid 5, however, significantly lower levels than MC3. Lipid 5 is detected in plasma, lung, and kidney, but not in heart[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

710.17

Formula

C₄₄H₈₇NO₅

CAS No.

2089251-33-0

SMILES

O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCO)CCCCCCCC(OCCCCCCCCC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Lipid 5Lipid5Lipid-5OthersmRNAaminolipidprimaryInhibitorinhibitorinhibit

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Lipid 5
Cat. No.:
HY-138171
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