2. Cytoskeleton
  3. Dynamin
  4. Dynole 2−24

Dynole 2−24 is an indole-based dynamin GTPase inhibitor (IC50=0.56 μM for dynamin I). Dynole 2−24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC₅₀(CME)=1.9 μM). Dynole 2−24 also shows 4.4-fold selectivity for dynamin I. Dynole 2−24 is active in-cell inhibitor of clathrin-mediated endocytosis. CME: Clathrin mediated endocytosis

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Dynole 2−24 Chemical Structure

Dynole 2−24 Chemical Structure

CAS No. : 1416313-72-8

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Description

Dynole 2−24 is an indole-based dynamin GTPase inhibitor (IC50=0.56 μM for dynamin I). Dynole 2−24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC₅₀(CME)=1.9 μM). Dynole 2−24 also shows 4.4-fold selectivity for dynamin I. Dynole 2−24 is active in-cell inhibitor of clathrin-mediated endocytosis[1]. CME: Clathrin mediated endocytosis

Molecular Weight

371.60

Formula

C24H41N3
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

CN(C)CCCN1C=C(CNCCCCCCCCCC)C2=C1C=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (269.11 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6911 mL 13.4553 mL 26.9107 mL
5 mM 0.5382 mL 2.6911 mL 5.3821 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6911 mL 13.4553 mL 26.9107 mL 67.2766 mL
5 mM 0.5382 mL 2.6911 mL 5.3821 mL 13.4553 mL
10 mM 0.2691 mL 1.3455 mL 2.6911 mL 6.7277 mL
15 mM 0.1794 mL 0.8970 mL 1.7940 mL 4.4851 mL
20 mM 0.1346 mL 0.6728 mL 1.3455 mL 3.3638 mL
25 mM 0.1076 mL 0.5382 mL 1.0764 mL 2.6911 mL
30 mM 0.0897 mL 0.4485 mL 0.8970 mL 2.2426 mL
40 mM 0.0673 mL 0.3364 mL 0.6728 mL 1.6819 mL
50 mM 0.0538 mL 0.2691 mL 0.5382 mL 1.3455 mL
60 mM 0.0449 mL 0.2243 mL 0.4485 mL 1.1213 mL
80 mM 0.0336 mL 0.1682 mL 0.3364 mL 0.8410 mL
100 mM 0.0269 mL 0.1346 mL 0.2691 mL 0.6728 mL
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Dynole 2−24 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dynole 2−241416313-72-8Dynaminclathrin mediated endocytosisdynamin GTPasenontoxicselectivityInhibitorinhibitorinhibit

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