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Chitosan (MW 150000) (Synonyms: Deacetylated chitin (MW 150000); Poly(D-glucosamine) (MW 150000))

Cat. No.: HY-B2144A
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Chitosan (MW 150000) (Deacetylated chitin (MW 150000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 150000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities.

For research use only. We do not sell to patients.

Chitosan (MW 150000) Chemical Structure

Chitosan (MW 150000) Chemical Structure

CAS No. : 9012-76-4

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Based on 1 publication(s) in Google Scholar

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Description

Chitosan (MW 150000) (Deacetylated chitin (MW 150000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 150000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities[1][2].

In Vitro

Chitosan (2 mg/mL; 48 hours; SKMEL28 and RPMI7951 cells) treatment presents a reduced growth potential[1].
Chitosan (2 mg/mL; 48 hours; RPMI7951 cells) treatment shows potent pro-apoptotic effects against RPMI7951 through the mitochondrial pathway[1].
Chitosan (2 mg/mL; 48 hours; RPMI7951 cells) treatment induces an up regulation of pro-apoptotic molecules such as Bax and a down regulation of anti-apoptotic proteins like Bcl-2 and Bcl-XL[1].
Low-molecular-weight chitosan can penetrate bacterial cell walls, bind with DNA and inhibit DNA transcription and mRNA synthesis, while high-molecular-weight Chitosan can bind to the negatively charged components on the bacterial cell wall. It forms an impermeable layer around the cell, changes cell permeability and blocks transport into the cell. Chitosan also can be used in water treatment, wound-healing materials, pharmaceutical excipient or drug carrier, obesity research and as a scaffold for tissue engineering[2].

Cell Viability Assay[1]

Cell Line: SKMEL28 and RPMI7951 cells
Concentration: 2 mg/mL
Incubation Time: 48 hours
Result: Presented a reduced growth potential.

Apoptosis Analysis[1]

Cell Line: RPMI7951 cells
Concentration: 2 mg/mL
Incubation Time: 48 hours
Result: Had potent pro-apoptotic effects against RPMI7951.

Western Blot Analysis[1]

Cell Line: RPMI7951 cells
Concentration: 2 mg/mL
Incubation Time: 48 hours
Result: Induced an up regulation of pro-apoptotic molecules such as Bax and a down regulation of anti-apoptotic proteins like Bcl-2 and Bcl-XL.
In Vivo

In chemical-induced colonic precancerous lesions in ICR mice, in the 2 weeks preventive experiments, mice fed with a diet containing high molecular weight Chitosan (HMWC) had significant fewer aberrant crypt foci formation than those fed with control diet. As the treatment extended to 6 weeks, both low molecular weight Chitosan (LMWC)- and HMWC-fed mice contained less aberrant crypt foci when compared to control[3].

Molecular Weight

150000.00(Average)

Formula

(C₆H₁₃NO₅)n

CAS No.

9012-76-4

SMILES
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Chitosan (MW 150000)Deacetylated chitin (MW 150000)Poly(D-glucosamine) (MW 150000)BacterialFungalPolysaccharidepolycationicantitumorantimicrobialantioxidantantibacterialantifungalpro-apoptoticInhibitorinhibitorinhibit

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Chitosan (MW 150000)
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