Chitosan (MW 150000)
Based on 3 publication(s) in Google Scholar
Chitosan (MW 150000) (Deacetylated chitin (MW 150000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 150000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities.
For research use only. We do not sell to patients.
- CAS No.: 9012-76-4
- Molecular Weight:150000 (Average)
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Chitosan (MW 150000)
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Biological Activity
Chitosan (2 mg/mL; 48 hours; SKMEL28 and RPMI7951 cells) treatment presents a reduced growth potential[1].
Chitosan (2 mg/mL; 48 hours; RPMI7951 cells) treatment shows potent pro-apoptotic effects against RPMI7951 through the mitochondrial pathway[1].
Chitosan (2 mg/mL; 48 hours; RPMI7951 cells) treatment induces an up regulation of pro-apoptotic molecules such as Bax and a down regulation of anti-apoptotic proteins like Bcl-2 and Bcl-XL[1].
Low-molecular-weight chitosan can penetrate bacterial cell walls, bind with DNA and inhibit DNA transcription and mRNA synthesis, while high-molecular-weight Chitosan can bind to the negatively charged components on the bacterial cell wall. It forms an impermeable layer around the cell, changes cell permeability and blocks transport into the cell. Chitosan also can be used in water treatment, wound-healing materials, pharmaceutical excipient or drug carrier, obesity research and as a scaffold for tissue engineering[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SKMEL28 and RPMI7951 cells
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Concentration:2 mg/mL
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Incubation Time:48 hours
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Result:Presented a reduced growth potential.
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Cell Line:RPMI7951 cells
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Concentration:2 mg/mL
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Incubation Time:48 hours
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Result:Had potent pro-apoptotic effects against RPMI7951.
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Cell Line:RPMI7951 cells
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Concentration:2 mg/mL
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Incubation Time:48 hours
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Result:Induced an up regulation of pro-apoptotic molecules such as Bax and a down regulation of anti-apoptotic proteins like Bcl-2 and Bcl-XL.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 9012-76-4
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Appearance Solid
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Molecular Weight 150000 (Average)
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Color White to light yellow
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SMILES
OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](N)[C@H](O[C@H]3[C@H](O)[C@@H](N)[C@H](O)O[C@@H]3CO)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]1O.[n].[MW 150000]
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Synonyms
Deacetylated chitin (MW 150000); Poly(D-glucosamine) (MW 150000)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Biomacromolecules
2025 Feb 10;26(2):1012-1022. PMID: 39836774 -
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Solvent & Solubility
0.1 M HCl : 16.67 mg/mL (ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Laure Gibot, et al. Anticancer properties of chitosan on human melanoma are cell line dependent. Int J Biol Macromol. 2015 Jan;72:370-9. [Content Brief]
[2]. Randy Chi Fai Cheung, et al. Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications. Mar Drugs. 2015 Aug 14;13(8):5156-86. [Content Brief]
[3]. Shyr-Yi Lin, et al. Chitosan prevents the development of AOM-induced aberrant crypt foci in mice and suppressed the proliferation of AGS cells by inhibiting DNA synthesis. J Cell Biochem. 2007 Apr 15;100(6):1573-80. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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