1. Metabolic Enzyme/Protease
  2. Glutathione Peroxidase
  3. N-Acetyl lysyltyrosylcysteine amide

N-Acetyl lysyltyrosylcysteine amide 

Cat. No.: HY-125039
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N-Acetyl lysyltyrosylcysteine amide is a potent, reversible, specific, and non-toxic tripeptide inhibitor of myeloperoxidase (MPO). N-Acetyl lysyltyrosylcysteine amide effectively inhibits MPO generation of toxic oxidants in vivo. N-Acetyl lysyltyrosylcysteine amide reduces neuronal damage and preserves brain tissue and neurological function in the stroked brain. N-Acetyl lysyltyrosylcysteine amide inhibits MPO-dependent hypochlorous acid (HOCl) generation, protein nitration, and LDL oxidation.

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N-Acetyl lysyltyrosylcysteine amide Chemical Structure

N-Acetyl lysyltyrosylcysteine amide Chemical Structure

CAS No. : 1287585-40-3

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Description

N-Acetyl lysyltyrosylcysteine amide is a potent, reversible, specific, and non-toxic tripeptide inhibitor of myeloperoxidase (MPO). N-Acetyl lysyltyrosylcysteine amide effectively inhibits MPO generation of toxic oxidants in vivo. N-Acetyl lysyltyrosylcysteine amide reduces neuronal damage and preserves brain tissue and neurological function in the stroked brain. N-Acetyl lysyltyrosylcysteine amide inhibits MPO-dependent hypochlorous acid (HOCl) generation, protein nitration, and LDL oxidation[1][2].

In Vivo

N-Acetyl lysyltyrosylcysteine amide (KYC) significantly decreases infarct size, blood-brain barrier leakage, infiltration of myeloid cells, loss of neurons, and apoptosis in the brains of middle cerebral artery occlusion (MCAO) mice[1].
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 3-7 days) significantly reduces neurological severity scores and infarct size in MCAO mice[1].
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily 7 days) significantly protects BBB function and decreased neutrophil infiltration. N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily 7 days) significantly reduces microglia/macrophage activation and neuron loss in MCAO mice. N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 3-7 days) decreases apoptosis and cell injury in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduced MPO in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduces NO2Tyr and 4-HNE in MCAO mice[1].

Animal Model: 8-10 weeks old C57BL/6J mice (middle cerebral artery occlusion (MCAO) mode)[1]
Dosage: 10 mg/kg
Administration: I.p.; daily for 3-7 days
Result: Significantly reduced neurological deficit and brain infarct size in mice subjected to MCAO.
Molecular Weight

453.56

Formula

C₂₀H₃₁N₅O₅S

CAS No.

1287585-40-3

SMILES

SC[[email protected]@H](C(N)=O)NC([[email protected]](CC1=CC=C(O)C=C1)NC([[email protected]](CCCCN)NC(C)=O)=O)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

N-Acetyl lysyltyrosylcysteine amideGlutathione Peroxidaseinfarctsizeblood-brainbarrierleakageinfiltrationmyeloidcellsneuronsMCAOmiceInhibitorinhibitorinhibit

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N-Acetyl lysyltyrosylcysteine amide
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