2. Apoptosis Metabolic Enzyme/Protease
  3. Glutathione Peroxidase
  4. Mitiperstat

Mitiperstat  (Synonyms: AZD4831)

Cat. No.: HY-145581 Purity: 98.07%
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Mitiperstat (AZD4831) is the potent inhibitor of myeloperoxidase (MPO). Mitiperstat is particularly useful in the research of prophylaxis of cardiovascular disorders such as heart failure and coronary artery disease related conditions (extracted from patent US20160152623A1).

For research use only. We do not sell to patients.

Mitiperstat Chemical Structure

Mitiperstat Chemical Structure

CAS No. : 1933460-19-5

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 528 In-stock
Solution
10 mM * 1 mL in DMSO USD 528 In-stock
Solid
5 mg USD 480 In-stock
10 mg USD 580 In-stock
25 mg USD 940 In-stock
50 mg USD 1250 In-stock
100 mg USD 1700 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Description

Mitiperstat (AZD4831) is the potent inhibitor of myeloperoxidase (MPO). Mitiperstat is particularly useful in the research of prophylaxis of cardiovascular disorders such as heart failure and coronary artery disease related conditions (extracted from patent US20160152623A1)[1].

IC50 & Target

MPO[1]
Clinical Trial
Molecular Weight

334.82

Formula

C15H15ClN4OS
CAS No.
Appearance

Solid

Color

Off-white to pink

SMILES

O=C(NC1=S)C(NC=C2)=C2N1CC3=C(C=C(C=C3)Cl)[C@H](N)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (373.33 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9867 mL 14.9334 mL 29.8668 mL
5 mM 0.5973 mL 2.9867 mL 5.9734 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9867 mL 14.9334 mL 29.8668 mL 74.6670 mL
5 mM 0.5973 mL 2.9867 mL 5.9734 mL 14.9334 mL
10 mM 0.2987 mL 1.4933 mL 2.9867 mL 7.4667 mL
15 mM 0.1991 mL 0.9956 mL 1.9911 mL 4.9778 mL
20 mM 0.1493 mL 0.7467 mL 1.4933 mL 3.7333 mL
25 mM 0.1195 mL 0.5973 mL 1.1947 mL 2.9867 mL
30 mM 0.0996 mL 0.4978 mL 0.9956 mL 2.4889 mL
40 mM 0.0747 mL 0.3733 mL 0.7467 mL 1.8667 mL
50 mM 0.0597 mL 0.2987 mL 0.5973 mL 1.4933 mL
60 mM 0.0498 mL 0.2489 mL 0.4978 mL 1.2444 mL
80 mM 0.0373 mL 0.1867 mL 0.3733 mL 0.9333 mL
100 mM 0.0299 mL 0.1493 mL 0.2987 mL 0.7467 mL
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Mitiperstat Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mitiperstat1933460-19-5AZD4831AZD 4831AZD-4831Glutathione PeroxidasemyeloperoxidaseMPOcardiovascular disorderheart failurecoronary artery diseaseInhibitorinhibitorinhibit

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