2. Others Metabolic Enzyme/Protease Apoptosis
  3. Isotope-Labeled Compounds Glutathione Peroxidase Cytochrome P450
  4. Mitiperstat-d3

Mitiperstat-d3 (AZD4831-d3) is the deuterated -labeled Mitiperstat (HY-145581).Mitiperstat (AZD4831) is an effective oral inhibitor of myeloperoxidase (MPO). Mitiperstat inhibits MPO and thyroid peroxidase (TPO) with IC50s of 1.5 nM and 0.69 μM. Mitiperstat exhibits a weak inhibitory activity against CYP3A4 with an IC50 of 6 μM. Mitiperstat can reduce inflammation and improve microvascular function, and it can be used in studies related to heart failure, preserved or mildly reduced ejection fraction, non-alcoholic fatty liver disease, and chronic obstructive pulmonary disease.

For research use only. We do not sell to patients.

Mitiperstat-d<sub>3</sub>

Mitiperstat-d3 Chemical Structure

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Other Forms of Mitiperstat-d3:

Mitiperstat-d3 Related Antibodies

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

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Description

Mitiperstat-d3 (AZD4831-d3) is the deuterated -labeled Mitiperstat (HY-145581).Mitiperstat (AZD4831) is an effective oral inhibitor of myeloperoxidase (MPO). Mitiperstat inhibits MPO and thyroid peroxidase (TPO) with IC50s of 1.5 nM and 0.69 μM. Mitiperstat exhibits a weak inhibitory activity against CYP3A4 with an IC50 of 6 μM. Mitiperstat can reduce inflammation and improve microvascular function, and it can be used in studies related to heart failure, preserved or mildly reduced ejection fraction, non-alcoholic fatty liver disease, and chronic obstructive pulmonary disease[1][2][3][4].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

IC50 & Target

IC50: 1.5 nM (MPO)[3]; 0.69 μM (TPO)[3]; 6 μM (CYP3A4)[3]
In Vivo
Animal Model: Mouse zymosan-induced neutrophilic peritonitis models[4]
Dosage: 0.01-10 μmol/kg (3.3482 ng/kg-3.3482 μg/kg)
Administration: po, single dose
Result: Inhibited the peroxidase activity in mouse peritoneal lavage fluid.
Molecular Weight

337.84

Formula

C15H12D3ClN4OS
Unlabeled CAS
SMILES

O=C(NC1=S)C(NC=C2)=C2N1CC3=C(C=C(C=C3)Cl)[C@H](N)C([2H])([2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Mitiperstat-d3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mitiperstat-d3AZD4831-d3Isotope-Labeled CompoundsGlutathione PeroxidaseCytochrome P450CYPsmyeloperoxidaseMPOcardiovascular disorderheart failurecoronary artery diseaseInhibitorinhibitorinhibit

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