2. Metabolic Enzyme/Protease
  3. Glutathione Peroxidase
  4. Verdiperstat

Verdiperstat  (Synonyms: AZD3241)

Cat. No.: HY-17646 Purity: 99.60%
COA Handling Instructions

Verdiperstat (AZD3241) is a selective, irreversible and orally active myeloperoxidase (MPO) inhibitor, with an IC50 of 630 nM, and can be used in the research of neurodegenerative brain disorders.

For research use only. We do not sell to patients.

Verdiperstat Chemical Structure

Verdiperstat Chemical Structure

CAS No. : 890655-80-8

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 50 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 50 In-stock
Solid
5 mg USD 90 In-stock
10 mg USD 150 In-stock
50 mg USD 450 In-stock
100 mg USD 700 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

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Description

Verdiperstat (AZD3241) is a selective, irreversible and orally active myeloperoxidase (MPO) inhibitor, with an IC50 of 630 nM, and can be used in the research of neurodegenerative brain disorders.

IC50 & Target

IC50: 630 nM (Myeloperoxidase)[1]
In Vitro

Verdiperstat (AZD3241) is a myeloperoxidase (MPO) inhibitor, with an IC50 of 630 nM, and is used in the research of neurodegenerative brain disorders[1]. Verdiperstat (AZD3241) selectively and irreversibly inhibits myeloperoxidase, and may involves reduction of oxidative stress leading to reduction of sustained neuroinflammation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

253.32

Appearance

Solid

Formula

C11H15N3O2S
CAS No.
SMILES

O=C(N1)C(NC=C2)=C2N(CCOC(C)C)C1=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (592.14 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9476 mL 19.7379 mL 39.4758 mL
5 mM 0.7895 mL 3.9476 mL 7.8952 mL
10 mM 0.3948 mL 1.9738 mL 3.9476 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.87 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.87 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.87 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Verdiperstat890655-80-8AZD3241AZD 3241AZD-3241Glutathione PeroxidaseInhibitorinhibitorinhibit

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