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Briquilimab

(Synonyms: JSP-191; AMG-191)
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Based on 1 Customer Validation

Briquilimab (JSP-191 or AMG-191) is a humanized IgG1 monoclonal antibody that binds human CD117 (c-Kit). Briquilimab blocks the interaction between CD117 receptor and stem cell factor on various CD117 expressing tissues. Briquilimab can lead to inhibition of SCF/c-Kit signaling and MC apoptosis. Briquilimab is a non-toxic approach to target and deplete HSC, enabling blood and immune reconstitution with minimal toxicity with the other agents being used for transient immune suppression to prevent immunologic rejection. Briquilimab can be used in various disease research such as severe combined immunodeficiency (SCID), myelodyplastic syndromes (MDS), acute myeloid leukemia (AML), chronic spontaneous urticarial (CSU), chronic inducible urticarial (CIndU) and asthema.

For research use only. We do not sell to patients.

  • Purity: 99.00%
  • CAS No.: 2574591-89-0
  • Molecular Weight:145.61 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Briquilimab
  • Experimental Validation Results for Briquilimab
  • Experimental Validation Results for Briquilimab
  • Experimental Validation Results for Briquilimab
  • Briquilimab Chemical Structure
    Briquilimab Chemical Structure
CAS No.: 2574591-89-0
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Briquilimab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Loaded Briquilimab on AHC2 biosensor, can bind CD117/c-kit Protein, Human (HEK293, His, HY-P72752) with an affinity constant of 5.634E-09 M as determined in BLI assay.

  • 1/16

    Immobilized Human c-Kit Protein (ECD, His Tag) can bind Briquilimab. The EC50 for this effect is 1.72 ng/mL.

  • 1/16

    Flow Cytometry analysis of THP-1 cells labelling c-Kit/CD117 (red) with Briquilimab (HY-P99488). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Briquilimab Chemical Structure
    1/16
  • Briquilimab
  • Loaded Briquilimab on AHC2 biosensor, can bind CD117/c-kit Protein, Human (HEK293, His, HY-P72752) with an affinity constant of 5.634E-09 M as determined in BLI assay.
  • Immobilized Human c-Kit Protein (ECD, His Tag) can bind Briquilimab. The EC50 for this effect is 1.72 ng/mL.
  • Flow Cytometry analysis of THP-1 cells labelling c-Kit/CD117 (red) with Briquilimab (HY-P99488). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).