1. Cell Cycle/DNA Damage
    Cytoskeleton
    Neuronal Signaling
  2. Microtubule/Tubulin
    Amyloid-β
  3. Davunetide

Davunetide 

Cat. No.: HY-105066
Handling Instructions

Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Davunetide Chemical Structure

Davunetide Chemical Structure

CAS No. : 211439-12-2

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1 mg USD 50 In-stock
Estimated Time of Arrival: December 31
5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 170 In-stock
Estimated Time of Arrival: December 31
25 mg USD 340 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity[1][2][3].

In Vivo

Davunetide (2 μg/kg; Intranasally; daily, 5 days a week, for 16 weeks) shows protective effects for central nervous system complications in a diabetes rat model[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (Induced by an i.p. streptozotocin (STZ) injection)[3]
Dosage: 2 μg/kg
Administration: Intranasally beginning on the day following the STZ injection and were given daily, 5 days a week, for 16 weeks
Result: Impaired spatial memory of the diabetic rats was observed in the water maze by attenuated learning curve and worsened performance in the probe memory test. Davunetide treatment significantly improved both measurements.
Clinical Trial
Molecular Weight

824.92

Formula

C₃₆H₆₀N₁₀O₁₂

CAS No.
Sequence Shortening

NAPVSIPQ

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 250 mg/mL (303.06 mM)

DMSO : 125 mg/mL (151.53 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2122 mL 6.0612 mL 12.1224 mL
5 mM 0.2424 mL 1.2122 mL 2.4245 mL
10 mM 0.1212 mL 0.6061 mL 1.2122 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (2.52 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Davunetide
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HY-105066
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