211439-12-2
Chemical Structure
Davunetide
- CAS No.: 211439-12-2
- Formula:C36H60N10O12
- Molecular Weight:824.92
IUPAC Name: L-asparaginyl-L-alanyl-L-prolyl-L-valyl-L-seryl-L-isoleucyl-L-prolyl-L-glutamine
InChIKey: DWLTUUXCVGVRAV-XWRHUKJGSA-N
SMILES: O=C(N(CCC1)[C@@H]1C(N[C@H](C(O)=O)CCC(N)=O)=O)[C@H]([C@@H](C)CC)NC([C@H](CO)NC([C@H](C(C)C)NC([C@H](CCC2)N2C([C@H](C)NC([C@@H](N)CC(N)=O)=O)=O)=O)=O)=O
Biological Activity: Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity[1][2][3].
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Davunetide | 98.57% | Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity. | ||||||||||||||||||||
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Davunetide (Standard) | ≥98% | Davunetide (Standard) is the analytical standard of Davunetide (HY-105066). This product is intended for research and analytical applications. Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity. | ||||||||||||||||||||
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Similarity Score 0.76
HY-P0289CEF3 -
Similarity Score 0.73
HY-P11152HIV-1 tat Protein (1-9) -
Similarity Score 0.73
HY-P10103Smac-N7 peptide -
Similarity Score 0.73
HY-P2636Cholecystokinin Precursor (24-32) (rat) -
Similarity Score 0.72
HY-P3716H(-Asn-Pro-Asn-Ala)2-OH -
Similarity Score 0.72
HY-P5346Smac-based peptide -
Similarity Score 0.72
HY-P10535AAV-8 NSL epitope -
Similarity Score 0.71
HY-106128Lagatide -
Similarity Score 0.71
HY-P11572NAVPITPTLNR -
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References
- [1]. Quraishe S, et al. NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy. Mol Psychiatry. 2013;18(7):834-842. [Content Brief]
- [2]. Zhang J, et al. Davunetide improves spatial learning and memory in Alzheimer's disease-associated rats. Physiol Behav. 2017;174:67-73. [Content Brief]
- [3]. Idan-Feldman A, et al. Davunetide (NAP) as a preventative treatment for central nervous system complications in a diabetes rat model. Neurobiol Dis. 2011;44(3):327-339. [Content Brief]
