SARS-CoV-2-IN-10
SARS-CoV-2-IN-10 is a potent and nontoxic inhibitor of SARS-CoV-2 3CL protease (3CLpro) with an IC50 and EC50 of 0.13 and 1.03 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals.
For research use only. We do not sell to patients.
- CAS No.: 2722634-95-7
- Formula: C27H37F2N3O5
- Molecular Weight:521.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
SARS-CoV-2 3C-like protease[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | CC50 |
>100 μM
Compound: 15b
|
Cytotoxicity against HEK293T cells assessed as reduction in cell viability measured after 72 hrs by CytoTox 96 nonradioactive cytotoxicity assay
Cytotoxicity against HEK293T cells assessed as reduction in cell viability measured after 72 hrs by CytoTox 96 nonradioactive cytotoxicity assay
|
[PMID: 34865476] |
Chemical Information
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CAS No. 2722634-95-7
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Molecular Weight 521.60
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Formula C27H37F2N3O5
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SMILES
O=C(NCC1)[C@@H]1C[C@@H](C=O)NC([C@H](CC(C)C)NC(OC(C2=CC=CC=C2)C3CCC(F)(CC3)F)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)