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ITX3 

Cat. No.: HY-16663 Purity: 98.88%
Handling Instructions

ITX3 is a specific and nontoxic inhibitor of TrioN (N-terminal GEF domain of the multidomain Trio protein) with an IC50 value of 76 μM. ITX3 can be used for the research of drug.

For research use only. We do not sell to patients.

ITX3 Chemical Structure

ITX3 Chemical Structure

CAS No. : 347323-96-0

Size Price Stock Quantity
5 mg USD 74 In-stock
Estimated Time of Arrival: December 31
10 mg USD 134 In-stock
Estimated Time of Arrival: December 31
50 mg USD 602 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    ITX3 purchased from MCE. Usage Cited in: J Genet Genomics. 2019 Feb;46(2):87-96.

    Western analysis of the related proteins levels with or without the treatment of ITX3.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    ITX3 is a specific and nontoxic inhibitor of TrioN (N-terminal GEF domain of the multidomain Trio protein) with an IC50 value of 76 μM. ITX3 can be used for the research of drug[1][2].

    IC50 & Target

    IC50: 76 μM (TrioN)[1]

    In Vitro

    ITX3 (5, 10, 25, 50 and 100 μM; 24 h) inhibits TrioN signaling[1].
    ITX3 (50 μM; 1 h) specifically inhibits TrioN[1].
    ITX3 (100 μM; 36 h) inhibits nerve growth factor-induced neurite outgrowth in PC12 cells[1].
    ITX3 (1, 10 and 100 μM) represses Rac1 activity and dose-dependently up-regulates the E-cadherin protein level and phospho-p38 signal in Tara-KD cells[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Western Blot Analysis[1]

    Cell Line: TrioN-, GEF337-, Tiam1- and Vav2-expressing HEK293 cell lines[1]
    Concentration: 50 μM
    Incubation Time: 1 hour
    Result: Decreased TrioN-induced Rac activity.
    Molecular Weight

    371.45

    Formula

    C22H17N3OS

    CAS No.
    SMILES

    O=C(/C1=C\C2=C(C)N(C(C)=C2)C3=CC=CC=C3)N4C(S1)=NC5=CC=CC=C45

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 2 mg/mL (5.38 mM; ultrasonic and warming and heat to 80°C)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.6922 mL 13.4608 mL 26.9215 mL
    5 mM 0.5384 mL 2.6922 mL 5.3843 mL
    10 mM --- --- ---
    *Please refer to the solubility information to select the appropriate solvent.
    Purity & Documentation
    References
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    Product Name:
    ITX3
    Cat. No.:
    HY-16663
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