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ITX3 

Cat. No.: HY-16663 Purity: 99.66%
Handling Instructions

ITX3 is a specific and nontoxic inhibitor of the TrioN (N-terminal GEF domain of the multidomain Trio protein) with IC50 of 76 uM; inhibits TrioN-stimulated RhoG exchange in vitro.

For research use only. We do not sell to patients.

ITX3 Chemical Structure

ITX3 Chemical Structure

CAS No. : 347323-96-0

Size Price Stock Quantity
5 mg USD 67 In-stock
Estimated Time of Arrival: December 31
10 mg USD 122 In-stock
Estimated Time of Arrival: December 31
50 mg USD 547 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE ITX3

    ITX3 purchased from MCE. Usage Cited in: J Genet Genomics. 2019 Feb;46(2):87-96.

    Western analysis of the related proteins levels with or without the treatment of ITX3.
    • Biological Activity

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    Description

    ITX3 is a specific and nontoxic inhibitor of the TrioN (N-terminal GEF domain of the multidomain Trio protein) with IC50 of 76 uM; inhibits TrioN-stimulated RhoG exchange in vitro. IC50 value: 76 uM [1] Target: TrioN inhibitor In transfected mammalian cells, ITX3 blocked TrioN-mediated dorsal membrane ruffling and Rac1 activation while having no effect on GEF337-, Tiam1-, or Vav2-mediated RhoA or Rac1 activation. ITX3 specifically inhibited endogenous TrioN activity, as evidenced by its ability to inhibit neurite outgrowth in nerve growth factor (NGF)–stimulated PC12 cells or C2C12 differentiation into myotubes [1]. ITX3 repressed the Rac1 activity and dose dependently up-regulated the E-cadherin protein level in the Tara-KD cells [2].

    Molecular Weight

    371.45

    Formula

    C₂₂H₁₇N₃OS

    CAS No.

    347323-96-0

    SMILES

    O=C(/C1=C\C2=C(C)N(C(C)=C2)C3=CC=CC=C3)N4C(S1)=NC5=CC=CC=C45

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 2 mg/mL (5.38 mM; ultrasonic and warming and heat to 80°C)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.6922 mL 13.4608 mL 26.9215 mL
    5 mM 0.5384 mL 2.6922 mL 5.3843 mL
    10 mM --- --- ---
    *Please refer to the solubility information to select the appropriate solvent.
    References
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    Keywords:

    ITX3ITX 3ITX-3OthersInhibitorinhibitorinhibit

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    Product Name:
    ITX3
    Cat. No.:
    HY-16663
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