347323-96-0
347323-96-0
Chemical Structure
ITX3
- CAS No.: 347323-96-0
- Formula:C22H17N3OS
- Molecular Weight:371.45
IUPAC Name: (E)-2-((2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)methylene)benzo[4,5]imidazo[2,1-b]thiazol-3(2H)-one
InChIKey: SJMYMKPBODEZSH-DEDYPNTBSA-N
SMILES: O=C(/C1=C\C2=C(C)N(C(C)=C2)C3=CC=CC=C3)N4C(S1)=NC5=CC=CC=C45
Biological Activity: ITX3 is a specific and nontoxic inhibitor of TrioN (N-terminal GEF domain of the multidomain Trio protein) with an IC50 value of 76 μM. ITX3 can be used for the research of agent[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ITX3 | 98.60% | ITX3 is a specific and nontoxic inhibitor of TrioN (N-terminal GEF domain of the multidomain Trio protein) with an IC50 value of 76 μM. ITX3 can be used for the research of agent. | ||||||||||||||||||||
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References
- [1]. Bouquier N, et al. A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway. Chem Biol. 2009 Jun 26;16(6):657-66. [Content Brief]
- [2]. Yano T, et al. Tara up-regulates E-cadherin transcription by binding to the Trio RhoGEF and inhibiting Rac signaling. J Cell Biol. 2011 Apr 18;193(2):319-32. [Content Brief]
