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Cat. No.: HY-159126

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SIRT2-IN-15

SIRT2-IN-15 (compound 1) is a SIRT2 deacetylase and deamyloacylase inhibitor with IC₅₀ 7 and 37 μM, respectively.

For research use only. We do not sell to patients.

CAS No.: 312275-43-7
Formula: C₁₆H₈BrIN₂O₂S
Molecular Weight:499.12

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

SIRT2-IN-15 Chemical Structure

CAS No.: 312275-43-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

SIRT2-IN-15 (compound 1) is a SIRT2 deacetylase and deamyloacylase inhibitor with IC₅₀ 7 and 37 μM, respectively^[1].

All Sirtuin Isoforms :

In Vitro

SIRT2-IN-15 (compound 1) can increase acetylated α - tubulin levels in A549 lung cancer cells by inhibiting SIRT2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 312275-43-7
Molecular Weight 499.12
Formula C₁₆H₈BrIN₂O₂S
SMILES

O=C1/C(SC2=NC3=C(N12)C=CC=C3)=C/C4=C(O)C(I)=CC(Br)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang J, et al. A homogeneous time-resolved fluorescence screen to identify SIRT2 deacetylase and defatty-acylase inhibitors. PLoS One. 2024 Jun 24;19(6):e0305000. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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