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Art. -Nr.: HY-120055

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CP-94707

CP-94707 is an HIV-1 reverse transcriptase (HIV-1 reverse transcriptase) inhibitor, with an IC₅₀ of 4 μM against wild-type and HIV-1 reverse transcriptase ^Y181I-Y188L double mutant enzymes, and an IC₅₀ of 10 μM against HIV-1 reverse transcriptase ^K103N mutant enzyme. CP-94707 inhibits the initiation of negative-strand DNA synthesis primed by tRNA^Lys-3, as well as the elongation of DNA synthesis mediated by HIV-1 reverse transcriptase. CP-94707 can be used in studies related to HIV infection.

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CAS. Nr.: 343250-05-5
Formel: C₂₁H₁₆N₄OS
Molecular Weight:372.44

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Please store the product under the recommended conditions in the Certificate of Analysis.

CP-94707 Chemical Structure

CAS. Nr.: 343250-05-5

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Beschreibung

Alle HIV Isoform-spezifische Produkte anzeigen :

In Vitro

CP-94,707 (0.10-32 μM; 45 min) inhibits tRNA^Lys-3-primed initiation activity of wild-type HIV-1 RT with an IC₅₀ of 4 μM, retains full activity against Y181I-Y188L double mutant HIV-1 RT (IC₅₀ = 4 μM), and shows only 2.5-fold reduced activity against K103N single mutant HIV-1 RT (IC₅₀ = 10 μM)^[1].
CP-94,707 (0.10-32 μM) inhibits elongation activity of wild-type HIV-1 RT with an IC₅₀ of 4 μM, demonstrating no selectivity for initiation over elongation steps^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 343250-05-5
Molecular Weight 372.44
Formel C₂₁H₁₆N₄OS
SMILES

O=C1SC2=CC=CC=C2N1CC3=CC=C(N4C(C)=NC5=C4C=CN=C5)C=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Pata JD, et al. Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 2004 Jul 20;101(29):10548-53.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

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Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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CP-94707

Alle HIV Isoform-spezifische Produkte anzeigen

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Chemical Information

Reinheit & Dokumentation

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CP-94707 Related Classifications

HY-120055 Related Classifications