1. Metabolic Enzyme/Protease
    NF-κB
  2. MALT1
  3. MALT1 inhibitor MI-2

MALT1 inhibitor MI-2 

Cat. No.: HY-12276 Purity: 99.56%
Handling Instructions

MALT1 inhibitor MI-2 is a MALT1 inhibitor (IC50=5.84 μM). MALT1 inhibitor MI-2 binds directly to MALT1, irreversibly suppresses protease function and is accompanied by NF-κB reporter activity suppression, c-REL nuclear localization inhibition, and NF-κB target gene downregulation. MALT1 inhibitor MI-2 shows nontoxic to animals.

For research use only. We do not sell to patients.

MALT1 inhibitor MI-2 Chemical Structure

MALT1 inhibitor MI-2 Chemical Structure

CAS No. : 1047953-91-2

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10 mM * 1 mL in DMSO USD 121 In-stock
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10 mg USD 150 In-stock
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50 mg USD 490 In-stock
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100 mg USD 850 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    MALT1 inhibitor MI-2 purchased from MCE. Usage Cited in: Parasit Vectors. 2018 May 18;11(1):305.

    The A20 protein levels in Jurkat T-cells and Molt-4 T-cells treated with MALT1 inhibitor MI-2 and combined use of MI-2 and ME-49.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    MALT1 inhibitor MI-2 is a MALT1 inhibitor (IC50=5.84 μM). MALT1 inhibitor MI-2 binds directly to MALT1, irreversibly suppresses protease function and is accompanied by NF-κB reporter activity suppression, c-REL nuclear localization inhibition, and NF-κB target gene downregulation. MALT1 inhibitor MI-2 shows nontoxic to animals[1].

    IC50 & Target

    IC50: 5.84 μM (MALT1)[1]

    In Vitro

    MALT1 inhibitor MI-2 (1-1000 nM; 48 hours) selectively suppresses MALT1-dependent DLBCL cell lines, and the GI50 in HBL-1, TMD8, OCI-Ly3, and OCI-Ly10 cells is 0.2, 0.5, 0.4, and 0.4 µM, respectively[1].
    MALT1 inhibitor MI-2 (62-1000 nM; 24 hours) causes a dose-dependent decrease in MALT1-mediated cleavage[1].

    Cell Proliferation Assay[1]

    Cell Line: HBL-1, TMD8, OCI-Ly3, OCI-Ly10 cells
    Concentration: 1, 10, 100, 1000 nM
    Incubation Time: 48 hours
    Result: The GI50 in HBL-1, TMD8, OCI-Ly3, and OCI-Ly10 cells was 0.2, 0.5, 0.4, and 0.4 µM, respectively.

    Western Blot Analysis[1]

    Cell Line: HBL-1 cells
    Concentration: 62, 125, 250, 500, 1000 nM
    Incubation Time: 24 hours
    Result: Inhibits MALT1 cleavage of CYLD in HBL-1 cells.
    In Vivo

    MALT1 inhibitor MI-2 (25 mg/kg; i.p.; daily for 14 days) profoundly suppresses the growth of both the TMD8 and HBL-1 ABC-DLBCL xenografts[1].

    Animal Model: Eight-week-old male SCID NOD (bearing HBL-1 and TMD8 cells)[1]
    Dosage: 25 mg/kg
    Administration: Intraperitoneal injection; daily for 14 days
    Result: Profoundly suppressed the growth of both the TMD8 and HBL-1 ABC-DLBCL xenografts versus vehicle.
    Molecular Weight

    455.72

    Formula

    C₁₉H₁₇Cl₃N₄O₃

    CAS No.

    1047953-91-2

    SMILES

    O=C(NC1=CC=C(N2N=C(OCCOC)N=C2C3=CC=C(Cl)C(Cl)=C3)C=C1)CCl

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 46 mg/mL (100.94 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1943 mL 10.9716 mL 21.9433 mL
    5 mM 0.4389 mL 2.1943 mL 4.3887 mL
    10 mM 0.2194 mL 1.0972 mL 2.1943 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.49 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.49 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.56%

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    MALT1 inhibitor MI-2
    Cat. No.:
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